Evidence map›Paper›PMID 41471867›Full record

ArticleMicroorganisms2025

Unraveling the Potential Antiviral Activity of Isoxazoline-Carbocyclic Monophosphate Nucleotides Against Echovirus 11.

Emilia Palazzotto, Valeria Stefanizzi, Floriana Bonura, Federica Cacioppo, Marco Leusciatti, Paolo Quadrelli, Annalisa Chianese, Carla Zannella, Anna De Filippis, Antonio Mastino and 2 more

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Study of Cytotoxicity of Pyrrolo[3,4-International journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Emilia PalazzottoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, Viale del Vespro Palermo 133, 90127 Palermo, Italy.
Valeria StefanizziDepartment of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.
Floriana BonuraDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, Viale del Vespro Palermo 133, 90127 Palermo, Italy.ORCID 0000-0002-9293-5924
Federica CacioppoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, Viale del Vespro Palermo 133, 90127 Palermo, Italy.ORCID 0000-0001-7072-5718
Marco LeusciattiINSTM Research Unit of Pavia, Department of Chemistry, University of Pavia, Viale Taramelli 10-12, 27100 Pavia, Italy.ORCID 0000-0002-6527-2571
Paolo QuadrelliINSTM Research Unit of Pavia, Department of Chemistry, University of Pavia, Viale Taramelli 10-12, 27100 Pavia, Italy.ORCID 0000-0001-5369-9140
Annalisa ChianeseDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-1648-4519
Carla ZannellaDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-7991-8700
Anna De FilippisDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-0395-7962
Antonio MastinoDepartment of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-0338-6450
Francesca Marino MerloDepartment of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.
Simona De GraziaDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, Viale del Vespro Palermo 133, 90127 Palermo, Italy.ORCID 0000-0001-7748-0880

Funding

European Union - Next Generation EU_CUP 2022W97H54_001
6 · The paper itself

Abstract

From July 2022, a novel Echovirus 11 (E11) variant has been associated with severe neonatal infections and liver failure. Currently, there are no vaccines or antiviral options for the targeted treatment of non-polio enterovirus (EV) infections; therefore, anti-EV drugs are urgently needed. In this study, the putative anti-E11 activity of two isoxzoline-carbocyclic monophosphate nucleotides (

Indexed as

antiviral activityEchovirus 11enterovirusisoxazoline-carbocyclic monophosphate nucleotides

Identifiers

PMID41471867
PMCPMC12734540

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.