ArticleMolecules (Basel, Switzerland)2025
Bromo Analogues of Active 3,4,5,4'-Tetramethoxy-
Dawid Łażewski, Gabriela Korzańska, Łukasz Popenda, Karolina Chmaj-Wierzchowska, Artur Korzański, Eduard Potapskyi, Julian Myszkiewicz, Agnieszka Gielara-Korzańska, Agnieszka Zgoła-Grześkowiak, Nataliya Finiuk and 6 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
16 authors.
Dawid ŁażewskiPoznan University of Medical Sciences, Department of Chemical Technology of Drugs, Grunwaldzka 6 Street, 60-780 Poznan, Poland.ORCID 0000-0002-9832-5094 Gabriela KorzańskaPoznan University of Medical Sciences, Department of Chemical Technology of Drugs, Grunwaldzka 6 Street, 60-780 Poznan, Poland.ORCID 0009-0000-6037-5056 Łukasz PopendaAdam Mickiewicz University, NanoBioMedical Centre, Wszechnicy Piastowskiej 3 Street, 61-614 Poznan, Poland.ORCID 0000-0003-1117-3081 Karolina Chmaj-WierzchowskaPoznan University of Medical Sciences, Department of Maternal and Child Health, 60-701 Poznan, Poland.ORCID 0000-0003-2299-8353 Artur KorzańskiAdam Mickiewicz University, Department of Chemistry, Uniwersytetu Poznanskiego 8 Street, 61-614 Poznan, Poland.ORCID 0000-0001-6207-6914 Eduard PotapskyiPoznan University of Medical Sciences, Department of Chemical Technology of Drugs, Grunwaldzka 6 Street, 60-780 Poznan, Poland.ORCID 0000-0002-5248-1091 Julian MyszkiewiczPoznan University of Medical Sciences, Department of Chemical Technology of Drugs, Grunwaldzka 6 Street, 60-780 Poznan, Poland.
Agnieszka Gielara-KorzańskaPoznan University of Medical Sciences, Department of Chemical Technology of Drugs, Grunwaldzka 6 Street, 60-780 Poznan, Poland.ORCID 0009-0004-4362-2915 Agnieszka Zgoła-GrześkowiakPoznan University of Technology, Institute of Chemistry and Technical Electrochemistry, Berdychowo 4, 60-965 Poznan, Poland.ORCID 0000-0002-9722-4769 Nataliya FiniukInstitute of Cell Biology of the National Academy of Sciences of Ukraine, Department of Regulation of Cell Proliferation and Apoptosis, Drahomanov Street 14/16, 79005 Lviv, Ukraine.ORCID 0000-0002-4112-8815 Yuliia KozakInstitute of Cell Biology of the National Academy of Sciences of Ukraine, Department of Regulation of Cell Proliferation and Apoptosis, Drahomanov Street 14/16, 79005 Lviv, Ukraine.ORCID 0000-0002-6793-0662 Iryna IvasechkoInstitute of Cell Biology of the National Academy of Sciences of Ukraine, Department of Regulation of Cell Proliferation and Apoptosis, Drahomanov Street 14/16, 79005 Lviv, Ukraine.ORCID 0000-0003-2789-0763 Roman LesykDanylo Halytsky Lviv National Medical University, Molecular Design Center, Pekarska 69, 79010 Lviv, Ukraine.ORCID 0000-0002-3322-0080 Joanna KuźmińskaPoznan University of Medical Sciences, Department of Pharmaceutical Chemistry, Rokietnicka 3, 60-806 Poznan, Poland.ORCID 0000-0002-8514-5238 Tomasz GoslinskiPoznan University of Medical Sciences, Department of Chemical Technology of Drugs, Grunwaldzka 6 Street, 60-780 Poznan, Poland.ORCID 0000-0001-5705-5414 Marcin WierzchowskiPoznan University of Medical Sciences, Department of Chemical Technology of Drugs, Grunwaldzka 6 Street, 60-780 Poznan, Poland.ORCID 0000-0003-2619-0466 Funding
National Research Foundation of Ukraine 2023.03/0104National Research Foundation of Ukraine 2023.05/0021National Science Centre 2019/35/B/NZ7/01165
6 · The paper itselfAbstract
Stilbenes are a group of polyphenols that are gaining steady attention and have promising biological activity. While much attention is given to polyhydroxy compounds derived from resveratrol, other substituents remain largely unexplored. In this work, we present the results of studies on the synthesis, physicochemical characterisation, and ADME parameters simulation of polymethoxy and brominated stilbenes. We also examined their anticancer activity and found that some of the brominated compounds reveal desirable properties. While the brominated derivatives are not significantly more active than the polymethoxy derivatives, they were found to be safer for the tested pseudo-normal cell lines.
Indexed as
Antineoplastic AgentsStilbenesCell Line, TumorHumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsStilbenesanticancer activitybrominated derivativesHorner-Wadsworth-Emmons reactiontrans-stilbenes
Identifiers
PMID41471812
PMCPMC12735739
What OpenQuestion holds
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LicenceCC BY
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