ArticleMolecules (Basel, Switzerland)2025
Stereoselective Cytotoxicity of Enantiopure 3,3-Dichloro-γ-lactams: Correlating In Vitro Activity with In Vivo Tolerability.
Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Everolimus Delivery via Lignin Nanoparticles Enhances Antitumor Activity in Hormone Receptor-Positive Breast Cancer.Precision chemistry · 2026Article
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3 authors.
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Abstract
Enantiopure γ-lactams have emerged as promising scaffolds for anticancer drug development, yet the influence of stereochemistry on their biological activity remains insufficiently explored. In this study, we evaluated the in vitro cytotoxicity and in vivo toxicity of selected enantiopure 3,3-dichloro-γ-lactams and their corresponding epimers, with particular focus on their selectivity toward tumor versus non-tumor cells. The compounds were synthesized through green photoredox processes and tested for cytotoxicity using MTT and NRU assays in human cancer cell lines (A431, HeLa, MCF-7) and non-tumor controls (3T3, HaCaT). Toxicity and tolerability were further assessed in vivo using zebrafish (Danio rerio) embryos. Among the series, compound
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