ArticleMolecules (Basel, Switzerland)2025
Design and Biological Evaluation of Monoterpene-Conjugated
Sergey A Borisov, Mikhail E Blokhin, Yulia V Meshkova, Maria K Marenina, Nataliya A Zhukova, Sophia V Pavlova, Anastasiya V Lastovka, Vladislav V Fomenko, Igor P Zhurakovsky, Olga A Luzina and 3 more
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In one paragraphArticle in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
Sergey A BorisovN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Akademika Lavrentieva Ave. 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-6415-5840 Mikhail E BlokhinN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Akademika Lavrentieva Ave. 9, 630090 Novosibirsk, Russia.ORCID 0000-0003-0532-0815 Yulia V MeshkovaN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Akademika Lavrentieva Ave. 9, 630090 Novosibirsk, Russia.
Maria K MareninaN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Akademika Lavrentieva Ave. 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-9500-1713 Nataliya A ZhukovaN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Akademika Lavrentieva Ave. 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-8496-0230 Sophia V PavlovaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Akademika Lavrentieva Ave. 10, 630090 Novosibirsk, Russia.ORCID 0000-0003-1095-3692 Anastasiya V LastovkaN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Akademika Lavrentieva Ave. 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-9170-6214 Vladislav V FomenkoN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Akademika Lavrentieva Ave. 9, 630090 Novosibirsk, Russia.ORCID 0000-0003-1827-3309 Igor P ZhurakovskyDepartment of Pathological Physiology and Clinical Pathophysiology, Faculty of Medicine, Novosibirsk State Medical University, Krasny Pr-t. 52, 630091 Novosibirsk, Russia.
Olga A LuzinaN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Akademika Lavrentieva Ave. 9, 630090 Novosibirsk, Russia.ORCID 0000-0001-8627-3453 Mikhail V KhvostovN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Akademika Lavrentieva Ave. 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-5906-4223 Dmitry A KudlayInstitute of Pharmacy, I. M. Sechenov First Moscow State Medical University, St. Trubetskaya 8/2, 119991 Moscow, Russia.ORCID 0000-0003-1878-4467 Nariman F SalakhutdinovN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Akademika Lavrentieva Ave. 9, 630090 Novosibirsk, Russia.
Funding
Russian Scientific Foundation 24-25-00120
6 · The paper itselfAbstract
Metabolic syndrome, a collective term for lipid and carbohydrate disorders in the organism, is the primary cause of type 2 diabetes mellitus development and its associated systemic side effects. The current approach for the medical treatment of this condition usually requires multiple medications, targeting multiple pathophysiological pathways. A promising drug class in that regard is the dual PPARα/γ agonists, which impact both lipid and carbohydrate metabolism, yet to this day the vast majority of them have not passed the clinical trials, due to potential toxicity risks. In the present study we synthesized and tested a series of monoterpene-substituted
Indexed as
Diabetes Mellitus, Type 2Hypoglycemic AgentsMonoterpenesPPAR alphaPPAR gammaPropionatesAnimalsDrug DesignHumansLipid MetabolismMaleMiceMice, Inbred C57BLHypoglycemic AgentsMonoterpenesPPAR alphaPPAR gammaPropionatesdual PPARα/γ agonistshypoglycemic activityhypolipidemic activitymetabolic syndromemonoterpenoidstype 2 diabetes mellitus
Identifiers
PMID41471798
PMCPMC12736036
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