Evidence map›Paper›PMID 41471777›Full record

ArticleMolecules (Basel, Switzerland)2025

Novel Adamantane-Sclareol Hybrids Exploit ROS Vulnerability to Overcome Multidrug-Resistance in Glioblastoma Cells.

Ema Lupšić, Pavle Stojković, Marija Grozdanić, Nataša Terzić-Jovanović, Milica Pajović, Fani Koutsougianni, Dimitra Alexopoulou, Igor M Opsenica, Milica Pešić, Ana Podolski-Renić

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ema LupšićInstitute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Despota Stefana 142, 11108 Belgrade, Serbia.ORCID 0000-0001-7824-1689
Pavle StojkovićUniversity of Belgrade-Faculty of Chemistry, P.O. Box 51, Studentski Trg 16, 11158 Belgrade, Serbia.ORCID 0000-0002-4660-5537
Marija GrozdanićInstitute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Despota Stefana 142, 11108 Belgrade, Serbia.ORCID 0009-0007-7425-685X
Nataša Terzić-JovanovićUniversity of Belgrade-Institute of Chemistry, Technology, and Metallurgy, National Institute of the Republic of Serbia, Njegoševa 12, 11000 Belgrade, Serbia.ORCID 0000-0002-4127-525X
Milica PajovićInstitute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Despota Stefana 142, 11108 Belgrade, Serbia.ORCID 0000-0001-7312-0861
Fani KoutsougianniDepartment of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Panepistimiou 3 (Biopolis), 41500 Larissa, Greece.
Dimitra AlexopoulouDepartment of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Panepistimiou 3 (Biopolis), 41500 Larissa, Greece.
Igor M OpsenicaUniversity of Belgrade-Faculty of Chemistry, P.O. Box 51, Studentski Trg 16, 11158 Belgrade, Serbia.
Milica PešićInstitute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Despota Stefana 142, 11108 Belgrade, Serbia.ORCID 0000-0002-9045-8239
Ana Podolski-RenićInstitute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Despota Stefana 142, 11108 Belgrade, Serbia.ORCID 0000-0001-7412-3685

Funding

Science Fund of the Republic of Serbia 7005
6 · The paper itself

Abstract

Multidrug resistance (MDR) presents a significant challenge in the treatment of glioblastoma. We evaluated six novel adamantane-sclareol hybrids that integrate a natural labdane diterpene scaffold with an adamantane moiety to address this issue. Compounds

Indexed as

AdamantaneDiterpenesDrug Resistance, MultipleDrug Resistance, NeoplasmGlioblastomaReactive Oxygen SpeciesAnimalsAntineoplastic AgentsApoptosisATP Binding Cassette Transporter, Subfamily B, Member 1Cell Line, TumorHumansMiceXenograft Model Antitumor AssaysAdamantaneAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily B, Member 1DiterpenesReactive Oxygen Speciesadamantanecollateral sensitivityglioblastomamultidrug resistanceoxidative stresssclareol

Identifiers

PMID41471777
PMCPMC12735718

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.