Evidence map›Paper›PMID 41471742›Full record

ArticleMolecules (Basel, Switzerland)2025

First In Vitro Human Islet Assessment of Oleanolic Acid (OA) and Its Serine Conjugate: Enhanced Solubility with Comparable Effects.

Runkai Yin, Li Zhao, Lina A Huang, Rui Zhao, Andy Wu, Maggie Rao, Jason Wu, Claire Wu, Fouad R Kandeel, Junfeng Li

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Runkai YinDepartment of Translational Research and Cellular Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Li ZhaoDepartment of Translational Research and Cellular Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Lina A HuangDepartment of Translational Research and Cellular Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Rui ZhaoDepartment of Translational Research and Cellular Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Andy WuDepartment of Translational Research and Cellular Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Maggie RaoDepartment of Translational Research and Cellular Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Jason WuDepartment of Translational Research and Cellular Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Claire WuDepartment of Translational Research and Cellular Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Fouad R KandeelDepartment of Translational Research and Cellular Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Junfeng LiDepartment of Translational Research and Cellular Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.ORCID 0000-0003-2398-7904

Funding

the Oxnard Foundation 50214-2012049
6 · The paper itself

Abstract

Oleanolic acid (OA) is a natural pentacyclic triterpenoid with reported hypoglycemic, hepatoprotective, antidiabetic, and anti-inflammatory activities. However, its limited aqueous solubility restricts its formulation and potential biomedical applications. To address this limitation, we designed a hydrophilic OA derivative,

Indexed as

Islets of LangerhansOleanolic AcidCell SurvivalChromatography, High Pressure LiquidHumansHydrophobic and Hydrophilic InteractionsSolubilityOleanolic Aciddiabeteshigh-performance liquid chromatography (HPLC)human islethydrophilicityimmunofluorescence stainingislet transplantationoctanol-water partition coefficientoleanolic acid (OA)viability

Identifiers

PMID41471742
PMCPMC12735548

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.