Evidence map›Paper›PMID 41471734›Full record

ArticleMolecules (Basel, Switzerland)2025

2-(Trihydroxyphenyl)thienopyrimidinones as Key Scaffolds for Targeting a Novel Allosteric Site of HIV-1 Integrase.

Graziella Tocco, Antonio Laus, Mattia Casula, Pierluigi Caboni, John A Beutler, Enzo Tramontano, Francesca Esposito

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Graziella ToccoDepartment of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, CA, Italy.ORCID 0000-0003-0081-5704
Antonio LausDepartment of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, CA, Italy.
Mattia CasulaDepartment of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, CA, Italy.ORCID 0000-0003-4300-3327
Pierluigi CaboniDepartment of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, CA, Italy.ORCID 0000-0003-2448-3767
John A BeutlerMolecular Targets Program, National Cancer Institute, Frederick, MD 21702, USA.ORCID 0000-0002-4646-1924
Enzo TramontanoDepartment of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, CA, Italy.ORCID 0000-0002-4849-0980
Francesca EspositoDepartment of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, CA, Italy.ORCID 0000-0001-9725-7977

Funding

Development of Natural Product Leads as Anticancer TherapeuticsZIABC011470 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BEUTLER, JOHN · 2012 to 2025
$7.8M
JAB was supported by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research ZIABC011470
6 · The paper itself

Abstract

A promising novel class of 2-(trihydroxyphenyl)thieno[2,3-

Indexed as

HIV-1HIV IntegraseHIV Integrase InhibitorsPyrimidinonesAllosteric RegulationAllosteric SiteBinding SitesHumansIntercellular Signaling Peptides and ProteinsModels, MolecularMolecular Docking SimulationProtein BindingStructure-Activity RelationshipHIV IntegraseHIV Integrase InhibitorsIntercellular Signaling Peptides and Proteinslens epithelium-derived growth factorp31 integrase protein, Human immunodeficiency virus 1PyrimidinonesHIV-1 Integrasenovel integrase allosteric inhibitorssucrose binding site

Identifiers

PMID41471734
PMCPMC12735844

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.