Evidence map›Paper›PMID 41471730›Full record

ArticleMolecules (Basel, Switzerland)2025

Safety of NADES Extract of

Veronika A Shikova, Olga N Pozharitskaya, Elena V Flisyuk, Dmitry Yu Ivkin, Dmitrii N Borovikov, Olga L Balabanova, Alexander N Shikov

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Veronika A ShikovaDepartment of Pharmaceutical Formulations, St. Petersburg State Chemical Pharmaceutical University, Prof. Popov Str., 14, 197376 Saint-Petersburg, Russia.ORCID 0000-0003-3028-4238
Olga N PozharitskayaMurmansk Marine Biological Institute of the Russian Academy of Sciences (MMBI RAS), Vladimirskaya Str., 17, 183038 Murmansk, Russia.ORCID 0000-0003-1061-0665
Elena V FlisyukDepartment of Pharmaceutical Formulations, St. Petersburg State Chemical Pharmaceutical University, Prof. Popov Str., 14, 197376 Saint-Petersburg, Russia.
Dmitry Yu IvkinCenter of Experimental Pharmacology, St. Petersburg State Chemical Pharmaceutical University, Prof. Popov Str., 14, 197376 Saint-Petersburg, Russia.ORCID 0000-0001-9273-6864
Dmitrii N BorovikovInfochemistry Scientific Center, School of Life Sciences, ITMO University, Lomonosov Str., 9, 191002 Saint-Petersburg, Russia.ORCID 0009-0008-8616-3543
Olga L BalabanovaDepartment of Pharmaceutical Chemistry, St. Petersburg State Chemical Pharmaceutical University, Prof. Popov Str., 14, 197376 Saint-Petersburg, Russia.ORCID 0000-0002-8636-9858
Alexander N ShikovDepartment of Pharmaceutical Formulations, St. Petersburg State Chemical Pharmaceutical University, Prof. Popov Str., 14, 197376 Saint-Petersburg, Russia.ORCID 0000-0003-4351-0695

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural deep eutectic solvents (NADES) have been extensively used for the extraction of a wide spectrum of plant materials. However, limited data about the in vivo toxicity of NADES extracts restrict their future practical application. In this study, we are aiming to assess the safety of a Sorbitol-lactic acid (3:1 mol./mol.; 30% water) NADES extract of

Indexed as

GlycyrrhizaPlant ExtractsPlant RootsSolventsAdministration, OralAdministration, TopicalAnimalsChromatography, LiquidFemaleMaleMiceSkinTandem Mass SpectrometryPlant ExtractsSolventsdermal toxicityGlycyrrhiza glabraLC-MS/MSNADES extractperoral administrationtoxicity

Identifiers

PMID41471730
PMCPMC12735871

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.