Evidence map›Paper›PMID 41471457›Full record

ArticleSensors (Basel, Switzerland)2025

Electrochemical Immunosensor Based on CS@AuNPs/ZIF-8/rGO Composite for Detecting CA15-3 in Human Serum.

Yuanyue Lu, Yong Mei, Yingying Gu, Ye Tao, Yuhan Yang, Jiao Yu, Yang Zhang, Lin Liu, Xin Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuanyue LuHubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Medical Sciences, Wuhan University of Science and Technology, Wuhan 430000, China.
Yong MeiHubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Medical Sciences, Wuhan University of Science and Technology, Wuhan 430000, China.
Yingying GuHubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Medical Sciences, Wuhan University of Science and Technology, Wuhan 430000, China.
Ye TaoHubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Medical Sciences, Wuhan University of Science and Technology, Wuhan 430000, China.
Yuhan YangHubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Medical Sciences, Wuhan University of Science and Technology, Wuhan 430000, China.
Jiao YuHubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Medical Sciences, Wuhan University of Science and Technology, Wuhan 430000, China.
Yang ZhangHubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Medical Sciences, Wuhan University of Science and Technology, Wuhan 430000, China.
Lin LiuHubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Medical Sciences, Wuhan University of Science and Technology, Wuhan 430000, China.
Xin LiHubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Medical Sciences, Wuhan University of Science and Technology, Wuhan 430000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An electrochemical immunosensor was fabricated to identify CA15-3, a biomarker for breast cancer (BC). A composite sensor substrate made of "zeolitic imidazolate framework-8" (ZIF-8) and "reduced graphene oxide" (rGO) was chosen and its conductivity was further improved by the addition of chitosan (CS)-doped gold nanoparticles (AuNPs). The CS@AuNPs are able to conjugate with antibodies via the strong Au-S interaction, which offers multiple active sites for antibody immobilization and enhances the sensor performance. This immunosensor is capable of ultrasensitive detection of CA15-3 by specific antigen-antibody -interactions. In healthy people, normal serum CA15-3 is up to 25 U/mL. Under optimized experimental conditions, the alteration in the signal intensity measured by the sensor was related to the CA15-3 activity. The quantitative relationship was linear over 0.001-400 U/mL with a limit of detection (LOD) of 0.0031 U/mL at a "signal-to-noise ratio" (S/N) of 3 and a "correlation coefficient" (r

Indexed as

Biosensing TechniquesElectrochemical TechniquesMetal NanoparticlesMucin-1Antibodies, ImmobilizedBreast NeoplasmsChitosanGoldGraphiteHumansImmunoassayLimit of DetectionAntibodies, ImmobilizedChitosanGoldgraphene oxideGraphiteMUC1 protein, humanMucin-1breast cancer tumor markerCA15-3gold nanoparticlesimmunosensormetal–organic frameworks

Identifiers

PMID41471457
PMCPMC12736644

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.