ArticlePharmaceuticals (Basel, Switzerland)2025
A Pyrimidine-Based Tubulin Inhibitor Shows Potent Anti-Glioblastoma Activity In Vitro and In Vivo.
Satyanarayana Pochampally, Lawrence M Pfeffer, Gustavo A Miranda-Carboni, Macey Daniel, Jazz I James, Allana Smith, Chuan He Yang, Hannah R Kelso, Deanna N Parke, Dong-Jin Hwang and 2 more
Abstract read
In one paragraphArticle in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Satyanarayana PochampallyDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0001-7617-9906 Lawrence M PfefferDepartment of Pathology and Laboratory Medicine, Center for Cancer Research, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-2809-1234 Gustavo A Miranda-CarboniDepartment of Medicine, Center for Cancer Research, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Macey DanielDepartment of Medicine, Center for Cancer Research, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Jazz I JamesDepartment of Pathology and Laboratory Medicine, Center for Cancer Research, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Allana SmithDepartment of Pathology and Laboratory Medicine, Center for Cancer Research, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Chuan He YangDepartment of Pathology and Laboratory Medicine, Center for Cancer Research, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Hannah R KelsoDepartment of Pathology and Laboratory Medicine, Center for Cancer Research, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0009-0001-6825-2170 Deanna N ParkeDepartment of Pathology and Laboratory Medicine, Center for Cancer Research, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0001-5125-683X Dong-Jin HwangDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-0055-1916 Wei LiDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-9522-4474 Duane D MillerDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-6093-0985 Funding
Targeting the colchicine site in tubulin for advanced melanomaR01CA148706 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LI, WEI, MILLER, DUANE D · 2011 to 2025
$5.3MTargeting brain and bone metastases in metastatic breast cancer for improved patient survivalR01CA276152 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WEI LI, Tiffany Nicole Seagroves · 2023 to 2026
$2.4MTherapeutic targeting of the SWI/SNF chromatin remodeler to regulate GBM chemosensitivityR01CA281977 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI DUANE D MILLER, LAWRENCE MARC PFEFFER · 2023 to 2026
$2.0MNational Insitute of Health R01CA276152National Institute of Health RO1CA281977National Intitute of Heath R01CA148706NCI NIH HHS R01 CA148706NCI NIH HHS R01 CA276152NCI NIH HHS R01 CA281977
6 · The paper itselfAbstract
PubMed holds no abstract for this paper.
Indexed as
cancerglioblastoma (GBM)microtubule-targeting agents (MTAs)pyrimidine dihydroquinoxalinone
Identifiers
PMID41471380
PMCPMC13019412
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