Evidence map›Paper›PMID 41471255›Full record

ArticlePathogens (Basel, Switzerland)2025

Ceftazidime-Avibactam Regimens for the Treatment of Bacteremic and Non-Bacteremic Episodes of Carbapenemase-Producing Enterobacterales Infections in Immunosuppressed Patients.

Fabián Herrera, Diego Torres, María Leone, Maximiliano Gabriel Castro, Jorge López Camelo, Elena Temporiti, Natalin Grippo, Silvia Relloso, Pablo Bonvehí

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fabián HerreraInfectious Diseases Section, Internal Medicine Department, Centro de Educación Médica e Investigaciones Clínicas, CEMIC, Buenos Aires C1431, Argentina.ORCID 0000-0001-8900-4400
Diego TorresInfectious Diseases Section, Internal Medicine Department, Centro de Educación Médica e Investigaciones Clínicas, CEMIC, Buenos Aires C1431, Argentina.ORCID 0009-0001-3831-4561
María LeoneInfectious Diseases Section, Internal Medicine Department, Centro de Educación Médica e Investigaciones Clínicas, CEMIC, Buenos Aires C1431, Argentina.ORCID 0009-0001-8039-2707
Maximiliano Gabriel CastroInfectious Diseases Section, Internal Medicine Department, Centro de Educación Médica e Investigaciones Clínicas, CEMIC, Buenos Aires C1431, Argentina.ORCID 0000-0003-0112-8455
Jorge López CameloCEMIC-CONICET Research Unit, Centro de Educación Médica e Investigaciones Clínicas, CEMIC, Buenos Aires C1431, Argentina.
Elena TemporitiInfectious Diseases Section, Internal Medicine Department, Centro de Educación Médica e Investigaciones Clínicas, CEMIC, Buenos Aires C1431, Argentina.
Natalin GrippoMicrobiology Laboratory, Centro de Educación Médica e Investigaciones Clínicas, CEMIC, Buenos Aires C1431, Argentina.
Silvia RellosoMicrobiology Laboratory, Centro de Educación Médica e Investigaciones Clínicas, CEMIC, Buenos Aires C1431, Argentina.
Pablo BonvehíInfectious Diseases Section, Internal Medicine Department, Centro de Educación Médica e Investigaciones Clínicas, CEMIC, Buenos Aires C1431, Argentina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ceftazidime-avibactam (CA) and CA plus aztreonam (ATM) are the preferred treatment options for KPC and MBL carbapenemase-producing Enterobacterales infections (CPEis). All episodes of monomicrobial CPEis in immunosuppressed patients (IPs) admitted from May 2019 to November 2024, who received definitive antibiotic therapy (AT) with CA or CA + ATM for at least 72 h, were prospectively included. Bacteremic episodes (BEs) and non-bacteremic episodes (NBEs) were compared. Logistic regressions adjusted by propensity score were used to identify variables associated with 30-day overall mortality. In total, 82 CPEis were included (38 NBEs and 44 BEs). BEs more frequently occurred in hematological malignancies (52.3% vs. 15.8%,

Indexed as

Anti-Bacterial AgentsAzabicyclo CompoundsBacteremiaCarbapenem-Resistant EnterobacteriaceaeCeftazidimeEnterobacteriaceae InfectionsImmunocompromised HostAdultAgedBacterial Proteinsbeta-LactamasesDrug CombinationsFemaleHumansMaleMiddle AgedAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo CompoundsBacterial Proteinsbeta-LactamasescarbapenemaseCeftazidimeDrug Combinationscarbapenemase-producing enterobacteralesceftazidime-avibactamimmunosuppressed patients

Identifiers

PMID41471255
PMCPMC12735816

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.