Evidence map›Paper›PMID 41471254›Full record

Observational studyPathogens (Basel, Switzerland)2025

Pentraxin 3 Levels Reflect Inflammatory and Parasitic Activity in Human Visceral Leishmaniasis.

Lucyo Flávio Bezerra Diniz, Milena Xavier Silva Barbosa, Samuel Ricarte de Aquino, Anderson da Costa Armstrong, Carlos Dornels Freire de Souza, Rodrigo Feliciano Carmo

Abstract readObservational Study
In one paragraph

Observational study in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lucyo Flávio Bezerra DinizPostgraduate Program in Health and Biological Sciences, Federal University of the São Francisco Valley (UNIVASF), Petrolina 56304-917, Pernambuco, Brazil.ORCID 0000-0001-7240-3851
Milena Xavier Silva BarbosaPostgraduate Program in Applied Cellular and Molecular Biology, University of Pernambuco (UPE), Recife 50100-130, Pernambuco, Brazil.ORCID 0000-0003-0034-9723
Samuel Ricarte de AquinoUniversity Hospital of the Federal University of the São Francisco Valley (HU-UNIVASF), Petrolina 56304-917, Pernambuco, Brazil.ORCID 0000-0002-6057-0414
Anderson da Costa ArmstrongUniversity Hospital of the Federal University of the São Francisco Valley (HU-UNIVASF), Petrolina 56304-917, Pernambuco, Brazil.ORCID 0000-0003-3161-8922
Carlos Dornels Freire de SouzaPostgraduate Program in Health and Biological Sciences, Federal University of the São Francisco Valley (UNIVASF), Petrolina 56304-917, Pernambuco, Brazil.ORCID 0000-0001-7995-1893
Rodrigo Feliciano CarmoPostgraduate Program in Health and Biological Sciences, Federal University of the São Francisco Valley (UNIVASF), Petrolina 56304-917, Pernambuco, Brazil.ORCID 0000-0001-9601-6995

Funding

Fundação de Amparo à Ciência e Tecnologia de Pernambuco IBPG-0245-2.02/24National Council for Scientific and Technological Development 302198/2025-3
6 · The paper itself

Abstract

Visceral leishmaniasis (VL) is a severe zoonotic disease characterized by high mortality and a pronounced systemic inflammatory response. Although Pentraxin 3 (PTX3) has been implicated in infectious and inflammatory disorders, its role in human VL remains poorly defined, and host-derived indicators that simultaneously reflect inflammatory and parasitic activity are limited. This study investigated the association between plasma PTX3 levels, parasite load, and

Indexed as

C-Reactive ProteinInflammationLeishmaniasis, VisceralSerum Amyloid P-ComponentAdolescentAdultBiomarkersCase-Control StudiesCytokinesFemaleHumansMaleMiddle AgedParasite LoadPentraxinsPolymorphism, Single NucleotideBiomarkersC-Reactive ProteinCytokinesPentraxinsSerum Amyloid P-Componentbiomarkerhost–pathogen interactioninflammationparasite loadPentraxin 3therapeutic responsevisceral leishmaniasis

Identifiers

PMID41471254
PMCPMC12736011

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.