ArticlePathogens (Basel, Switzerland)2025
Distribution of High-Risk HPV in Cervical Versus Oropharyngeal Samples: Results from a Prospective Screening Study in a Cohort of European Women of Reproductive Age.
Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
High-risk human papillomavirus (HR-HPV) infection with genotypes such as HPV-16 and HPV-18 is a well-established risk factor for cervical cancer; however, its prevalence in oropharyngeal sites among asymptomatic women remains less clearly defined. We evaluated 400 women aged 20-40 years (mean age 29.6 years) for the presence of HPV-16, HPV-18, and other HR-HPV genotypes in both cervical and oropharyngeal samples. Cervical specimens were collected using flocked swabs, and oropharyngeal specimens using flocked nylon swabs. Samples were preserved in transport medium, transported at 4-8 °C, and stored at -20 °C until DNA extraction. Viral DNA was isolated with the AA Viral DNA Kit and analyzed using the GenoProf HPV Screening Test, which employs multiplex PCR and reverse hybridization. HPV-16 was detected in 9.5% of participants, HPV-18 in 7.3%, and other HR-HPV genotypes in 14.3%. No statistically significant variation in prevalence across age groups was observed (HPV-16: χ
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