ArticlePathogens (Basel, Switzerland)2025
Retrospective Evaluation of the Incidence, Clinical Characteristics and Outcomes of Gram-Negative Bacterial Infections in Patients with Hematologic Malignancies.
Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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6 authors.
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Abstract
backgroundPatients with hematologic malignancies are highly vulnerable to Gram-negative bacterial bloodstream infections (GNB-BSIs) due to underlying disease-related immunosuppression, intensive chemotherapy, and repeated invasive interventions, rendering these infections a significant cause of morbidity and mortality in this population. This study aimed to evaluate the epidemiological, clinical, and microbiological features of GNB-BSIs in hospitalized patients with hematologic malignancies, and to compare clinical and microbiological factors between survivors and non-survivors.
methodsWe conducted a retrospective cohort study in a tertiary university hospital hematology ward in Türkiye, including adult patients diagnosed with BSIs due to Gram-negative bacteria between January 2005 and December 2024. Demographic characteristics, microbiological profiles, antimicrobial resistance rates, and clinical outcomes were analyzed. We compared survivors and non-survivors to determine differences in clinical and microbiological characteristics.
resultsA total of 321 patients with hematologic malignancies experienced 441 episodes of GNB-BSIs. The median age was 46 years, and 59% of them were male. The most frequently isolated pathogen was
conclusionsIn patients with hematologic malignancies,
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