ArticlePathogens (Basel, Switzerland)2025
IL-5 and IP-10 Detected in Quantiferon Supernatants Distinguish Latent Tuberculosis from Healthy Individuals in Areas with High Burden in Lima, Peru.
Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic accuracy ofFrontiers in immunology · 2026Pooled it
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7 authors.
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Abstract
backgroundPeru ranks among the countries with the highest burden of tuberculosis in Latin America. Interferon Gamma Release Assays (IGRAs), such as QuantiFERON-TB (QFT), cannot distinguish latent tuberculosis infection (LTBI) from active tuberculosis (ATB), but they provide a more specific and quantitative assessment of prior exposure to
methodsWe enrolled 56 participants and measured 38 cytokines/chemokines from plasma obtained through QFT in patients with active TB (n = 11), LTBI (n = 17), and QFT-negative healthy controls (n = 28) using a Multiplex Bead Assay.
resultsLevels of IL-1RA, IL-2, IL-5, IFN-γ, and IP-10 significantly differentiated both ATB and LTBI groups from healthy controls (
conclusionsBeyond IFN-γ as a differential proinflammatory cytokine in TB, cytokines such as IL-5, and IP-10 show potential as biomarkers to discriminate infection status in high-burden TB settings.
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