Evidence map›Paper›PMID 41471051›Full record

ArticlePharmaceutics2025

Interpretable Artificial Neural Network Models for Predicting Anti-Adalimumab Immune Complex and Serum Drug Level in Crohn's Disease: A Proof-of-Concept Study.

Livia Moreira Genaro, Juliana Carron, Gustavo Jacob Lourenço, Cristiane Kibune Nagasako, Glaucia Fernanda Soares Rupert Reis, Michel Gardere Camargo, Priscilla de Sene Portel Oliveira, Carmen Silvia Passos Lima, Maria de Lourdes Setsuko Ayrizono, Anibal Tavares de Azevedo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Livia Moreira GenaroInflammatory Bowel Disease Research Laboratory (LabDII), Gastrocenter, Colorectal Surgery Unit, Surgery Department, School of Medical Sciences, University of Campinas (Unicamp), Carlos Chagas Street, 420, Cidade Universitária Zeferino Vaz, Campinas 13083-878, SP, Brazil.ORCID 0000-0002-4640-6554
Juliana CarronLaboratory of Cancer Genetics (Lageca), School of Medical Sciences, University of Campinas (Unicamp), Campinas 13083-887, SP, Brazil.
Gustavo Jacob LourençoLaboratory of Cancer Genetics (Lageca), School of Medical Sciences, University of Campinas (Unicamp), Campinas 13083-887, SP, Brazil.ORCID 0000-0002-5944-0305
Cristiane Kibune NagasakoGastroenterology Unit, School of Medical Sciences, University of Campinas (Unicamp), Campinas 13083-887, SP, Brazil.ORCID 0000-0002-8403-1677
Glaucia Fernanda Soares Rupert ReisGastroenterology Unit, School of Medical Sciences, University of Campinas (Unicamp), Campinas 13083-887, SP, Brazil.
Michel Gardere CamargoInflammatory Bowel Disease Research Laboratory (LabDII), Gastrocenter, Colorectal Surgery Unit, Surgery Department, School of Medical Sciences, University of Campinas (Unicamp), Carlos Chagas Street, 420, Cidade Universitária Zeferino Vaz, Campinas 13083-878, SP, Brazil.
Priscilla de Sene Portel OliveiraInflammatory Bowel Disease Research Laboratory (LabDII), Gastrocenter, Colorectal Surgery Unit, Surgery Department, School of Medical Sciences, University of Campinas (Unicamp), Carlos Chagas Street, 420, Cidade Universitária Zeferino Vaz, Campinas 13083-878, SP, Brazil.ORCID 0000-0002-7519-2495
Carmen Silvia Passos LimaLaboratory of Cancer Genetics (Lageca), School of Medical Sciences, University of Campinas (Unicamp), Campinas 13083-887, SP, Brazil.
Maria de Lourdes Setsuko AyrizonoInflammatory Bowel Disease Research Laboratory (LabDII), Gastrocenter, Colorectal Surgery Unit, Surgery Department, School of Medical Sciences, University of Campinas (Unicamp), Carlos Chagas Street, 420, Cidade Universitária Zeferino Vaz, Campinas 13083-878, SP, Brazil.
Anibal Tavares de AzevedoSimulation Laboratory, School of Applied Sciences, University of Campinas, Limeira 13484-350, SP, Brazil.
Raquel Franco LealInflammatory Bowel Disease Research Laboratory (LabDII), Gastrocenter, Colorectal Surgery Unit, Surgery Department, School of Medical Sciences, University of Campinas (Unicamp), Carlos Chagas Street, 420, Cidade Universitária Zeferino Vaz, Campinas 13083-878, SP, Brazil.ORCID 0000-0003-4285-4402

Funding

National Council for Scientific and Technological Development (CNPq) #140462/2020-1 (L.M.G.) and #302557/2021-0 (R.F.L.)São Paulo Research Foundation (FAPESP) #2020/01924-5 (L.M.G)
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adalimumabartificial intelligenceCrohn’s diseaseimmune complexesimmunogenicity

Identifiers

PMID41471051
PMCPMC12735940

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.