Evidence map›Paper›PMID 41470971›Full record

ReviewPolymers2025

Mannans as Multifunctional Biopolymers: Structure, Properties, and Applications in Health and Industry.

Isaac Karimi, Layth Jasim Mohammed, Ahmed Makki Amshawee, Nahlah Fatehi Makki, Kosar Nazari, Helgi B Schiöth

Abstract readReview
In one paragraph

Review in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Isaac KarimiResearch Group of Bioengineering and Biotechnology, Laboratory for Computational Physiology, Department of Biology, Faculty of Science, Razi University, Kermanshah 67149-67346, Iran.ORCID 0000-0001-7415-0472
Layth Jasim MohammedDepartment of Microbiology, College of Medicine, Babylon University, Hilla City 51002, Iraq.ORCID 0000-0002-9340-8229
Ahmed Makki AmshaweeDepartment of Radiology, College of Health and Medical Technology, University of Hilla, Hilla City 51002, Iraq.
Nahlah Fatehi MakkiDepartment of Chemistry, College of Science, Kufa University, Najaf 54001, Iraq.ORCID 0000-0002-6249-5737
Kosar NazariResearch Group of Bioengineering and Biotechnology, Laboratory for Computational Physiology, Department of Biology, Faculty of Science, Razi University, Kermanshah 67149-67346, Iran.
Helgi B SchiöthDepartment of Surgical Sciences, Functional Pharmacology and Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.ORCID 0000-0001-7112-0921

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mannans are structurally composed of β-(1 → 4)-linked mannose units, which are widely distributed in plant cell walls, yeast, and bacterial exopolysaccharides. Mannans have emerged as multipurpose biopolymers with significant industrial and biomedical potential. Celebrated mannans include guar gum, locust bean gum, konjac glucomannan, yeast mannans, and softwood glucomannans. This comprehensive review highlights the sources, structural diversity, extraction methods, physicochemical properties, safety, and functional characteristics. The major bioactivities of mannans, including immunomodulatory, antioxidative, and prebiotic effects, reflect their relevance in biopharmaceutical applications. Moreover, mannans serve as valuable raw materials for developing biodegradable films, hydrogels, and nanocomposites applied in sustainable materials and drug delivery systems. Despite promising applications, challenges related to their large-scale production, standardization, and functional optimization remain to be investigated. Future perspectives focus on integrating advanced biotechnological approaches and chemical modifications to enhance the functional versatility of mannans. Overall, mannans represent a sustainable, multifunctional biopolymer with expanding applications across food, pharmaceutical, and biomedical industries.

Indexed as

biopolymerdrug deliverymannannanocompositesnutraceuticalsprebiotics

Identifiers

PMID41470971
PMCPMC12736695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.