Trial reportBMC complementary medicine and therapies2025
Effect of laughter yoga on anxiety and depression in people with Parkinson's disease: a randomized controlled trial.
Trial report in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Comparative effects of structured exercise protocols on depression and anxiety symptoms: a network meta-analysis.Frontiers in psychiatry · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundThe large number of people with Parkinson’s disease (PD) with anxiety or depression in China is a cause of concern. Sustained aerobic exercise is a promising therapy for delaying motor disabilities in people with PD. Laughter yoga is an aerobic training program that has proven to be beneficial in affecting the mental and physical aspects of healthy individuals, but its effect on anxiety and depression in people with PD has not been studied in controlled trials. The aim of this study was to assess the effectiveness of laughter yoga on anxiety, depression, sleep quality, and quality of life in people with PD.
methodsA randomized controlled trial design was used in this study. Ninety-four participants were randomly divided into two groups: 47 in the control group and 47 in the laughter yoga group. All participants received disease-related health education. The intervention group performed laughter yoga exercises, which consisted of two team exercises and five autonomous exercises per week. Participants exercised 20 min per session for 8 weeks. The primary outcomes were the Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) scores. The secondary outcomes were Parkinson’s Disease Sleep Scale (PDSS) and Parkinson’s Disease Quality of Life Scale-39 (PDQ-39) scores.
resultsNinety-four participants were included in the study. At baseline, there were no significant differences between the groups in terms of any demographic, anthropometric, clinical, or outcome characteristics. After intervention, the HAMA and HAMD scores were significantly lower in the laughter yoga group than in the control group (P < 0.05). Additionally, the PDQ-39 score was significantly lower in the laughter yoga group than in the control group (P < 0.05). There was no significant difference in the PDSS scores between the laughter yoga and control groups (P > 0.05).
conclusionsThe study results indicate that laughter yoga is an effective intervention for reducing anxiety and depression symptoms and improving the quality of life in people with PD.
trial registrationThe trial was registered retrospectively on May 30, 2022 (ChiCTR2200060401).
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