ArticleAntimicrobial resistance and infection control2025
Intestinal colonisation with extended-spectrum beta-lactamase-producing Enterobacterales and the impact of selected factors on intestinal colonisation duration: a prospective cohort study.
Article in Antimicrobial resistance and infection control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Multidrug-resistant organism carriage in Vietnamese district hospitals before and after an antimicrobial stewardship intervention.Antimicrobial resistance and infection control · 2026Article
- Lessons learned in the implementation of a study to evaluate intestinal colonization with antibiotic-resistant bacteria in communities and hospitals in India.Frontiers in public health · 2026Article
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8 authors.
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Abstract
introductionWe conducted a prospective cohort study of patients with newly acquired extended-spectrum beta-lactamase-producing Enterobacterales (ESBLPE) intestinal colonisation (termed "ESBLPE colonisation") in two public hospitals between January 2013 and October 2016. We evaluated the duration of ESBLPE colonisation and the impact of selected factors on this duration.
methodsPatient data and faeces samples were collected on enrolment and three monthly for 2 years. Standard laboratory methods were used for ESBLPE identification and susceptibility testing. Whole-genome sequencing of isolates was performed determining sequence type, plasmid replicons, antimicrobial resistance genes, virulence factor genes and phylogenetic relationships.
resultsThe median duration of ESBLPE colonisation for the 102 patients was 544 days (range 77-730 days, interquartile range 220-730 days). After one year and at the end of follow up, 61% and 23.4% of patients respectively remained ESBLPE colonised. The same strain of ESBLPE, colonised 70.2% (33/47) patients colonised with Escherichia coli and 70.7% (29/42) patients colonised with Klebsiella pneumoniae. Prolonged ESBLPE colonisation was associated with age ≥ 75 years (HR 0.46, 95% CI 0.23-0.90), an increased intensity of hospitalisation (P = 0.0036), E. coli phylogroup B2 (P = 0.0142), E. coli harbouring bla
conclusionsIt is likely that combinations of multiple patient and bacterial factors influence the duration of ESBLPE colonisation. This prolonged duration of ESBLPE colonisation highlights the importance of infection control and public health measures to decrease the acquisition and spread of ESBLPE.
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