Evidence map›Paper›PMID 41469861›Full record

ArticleBMC infectious diseases2025

Clinical characteristics and survival among HIV-infected people undergoing maintenance hemodialysis: a comparative study from Shanghai, China.

Xiaoqin Le, Nan Chen, Meipeng Wu, Qiongqiong Li, Qingmei Yang, Jun Chen, Renfang Zhang, Li Liu, Yinzhong Shen

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. A review of bloodstream infections-pathogens, pathogenesis, diagnostic strategies, treatment methods-challenges and future aspects.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  4. A review of bloodstream infections-pathogens, pathogenesis, diagnostic strategies, treatment methods-challenges and future aspects.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  5. A review of bloodstream infections-pathogens, pathogenesis, diagnostic strategies, treatment methods-challenges and future aspects.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoqin Le *Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Nan Chen *Department of Nephrology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Meipeng WuDepartment of Nephrology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Qiongqiong LiDepartment of Nephrology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Qingmei YangDepartment of Nephrology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Jun ChenDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Renfang ZhangDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Li LiuDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China. liuli@shphc.org.cn.
Yinzhong ShenDepartment of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China. shenyinzhong@shphc.org.cn.

Funding

Science and Technology Commission of Shanghai Municipality, grant number 20MC1920100Shanghai hospital development center, grant number SHDC22024317Shanghai Municipal Science and Technology Major Project ZD2021CY001
6 · The paper itself

Abstract

backgroundMortality remains high among people living with HIV (PLHIV) undergoing maintenance hemodialysis (MHD). However, data on the survival of MHD patients in first-tier Chinese cities are limited. This study aimed to analyze the clinical characteristics and survival of PLHIV receiving MHD in Shanghai.

methodsWe conducted a retrospective cohort study at the Blood Purification Center of Shanghai Public Health Clinical Center. Clinical data were collected for PLHIV and HIV-negative controls who initiated MHD between November 2011 and September 2023. Survival was compared using Kaplan-Meier curves, and risk factors were identified through Cox regression analyses.

resultsThe study included 45 PLHIV and 54 HIV-negative individuals who underwent MHD for over three months. PLHIV were significantly younger at MHD initiation and had a higher proportion of males compared to controls (54.4 ± 14.4 vs. 61.6 ± 16.5 years, p = 0.025; 88.9% vs. 64.8%, p = 0.005). At baseline, the mean CD4 count for PLHIV was 261.1 ± 155.2 cells/µL, and 66.7% (30/45) had undetectable viral loads. The maximum follow-up durations were 145 months for PLHIV and 107 months for controls, with median survival times of 45 months and 61 months, respectively. Survival rates at 12, 24, 36, and 60 months were lower in the HIV group than in the control group (74.8% vs. 88.7%, 71.4% vs. 80.2%, 67.2% vs. 67.7%, and 33.2% vs. 67.7%), with a statistically significant difference observed only at 60 months (p = 0.0343). The overall difference in cumulative survival probability between the two groups was not significant (Log-rank test, p = 0.15). After adjusting for covariates, age ≥ 60 years at MHD initiation was significantly associated with reduced survival in both PLHIV (hazard ratio [HR] 3.14, 95% confidence interval [CI]: 1.15-8.54, p = 0.025) and the entire patient cohort (HR 3.15, 95% CI: 1.31-7.58, p = 0.01).

conclusionPLHIV initiated MHD at a younger age but exhibited lower long-term survival rates, particularly at 60 months, compared to HIV-negative individuals. Age ≥ 60 years at dialysis initiation was an independent risk factor for mortality in PLHIV.

trial registrationNot applicable.

Indexed as

HIV InfectionsRenal DialysisAdultAgedCD4 Lymphocyte CountChinaFemaleHumansKaplan-Meier EstimateMaleMiddle AgedRetrospective StudiesRisk FactorsMaintenance hemodialysisPeople living with HIVSurvival rate

Identifiers

PMID41469861
PMCPMC12859888

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.