Evidence map›Paper›PMID 41469838›Full record

ArticleCellular and molecular life sciences : CMLS2025

Secretoglobin 3A1 in activated muscle satellite cells contributes to myosin heavy chain IIX and IIB fiber differentiation.

Shigetoshi Yokoyama, Taketomo Kido, Mitsuhiro Yoneda, Danielle A Springer, Parirokh P Awasthi, Raj Chari, Andrew D Patterson, Shioko Kimura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shigetoshi YokoyamaCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, Maryland, 20892, USA.ORCID http://orcid.org/0000-0003-4175-0548
Taketomo KidoCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, Maryland, 20892, USA.
Mitsuhiro YonedaCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, Maryland, 20892, USA.ORCID http://orcid.org/0000-0001-6340-1205
Danielle A SpringerMurine Phenotyping Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, Maryland, 20892, USA.
Parirokh P AwasthiLaboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.ORCID http://orcid.org/0000-0002-5831-9781
Raj ChariLaboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.ORCID http://orcid.org/0000-0002-2216-313X
Andrew D PattersonDepartment of Veterinary and Biomedical Sciences, Penn State University, University Park, PA, 16802, USA.ORCID http://orcid.org/0000-0003-2073-0070
Shioko KimuraCancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, Maryland, 20892, USA. kimuras@mail.nih.gov.ORCID http://orcid.org/0000-0001-9627-6818

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle has an innate ability to restore damaged muscle fibers by contributing specific progenitor cells, called muscle satellite cells. Here we show that secretoglobin (SCGB) 3A1, a tumor suppressor gene in various malignancies including rhabdomyosarcoma, is induced just after muscle injury and contributes to damaged muscle fiber regeneration. Lineage tracing of SCGB3A1 in mice show that SCGB3A1-positive cells highly express myosin heavy chain (MyHC)-IIX in damaged fiber area. Scgb3a1-null and Pax7

Indexed as

Cell DifferentiationMuscle Fibers, SkeletalMyosin Heavy ChainsNonmuscle Myosin Type IIBSatellite Cells, Skeletal MuscleSecretoglobinsAnimalsMiceMice, Inbred C57BLMice, KnockoutMuscle, SkeletalReceptor, Notch3RegenerationMyosin Heavy ChainsNonmuscle Myosin Type IIBReceptor, Notch3SecretoglobinsMuscle regenerationMuscle satellite cellsMyosin heavy chainNotch signalingPAX7SCGB3A1

Identifiers

PMID41469838
PMCPMC12804533

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.