ArticleScientific reports2025
A novel chromatography method for high purity production of Recombinant human parathyroid hormone from E. coli.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Human parathyroid hormone (hPTH) shows great potential as a therapeutic option for osteoporosis in patients who do not respond sufficiently to conventional therapies. We utilize recombinant DNA technology to enhance the drug development process and introduce a state-of-the-art purification protocol for the first 34 residues of human parathyroid hormone (hPTH), as these residues are responsible for the majority of its hormonal activity. Typically, the purification of recombinant human parathyroid hormone has relied on His-Tag fusion partners using Ni²⁺-chelating chromatography. This is the first time ion exchange chromatography has been used for the soluble PTH form, and no reports of ion exchange chromatography for this purpose have been documented. SUMO-tag technology and a three-step chromatography process were used to purify recombinant human parathyroid hormone [rhPTH
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