ArticleHuman genomics2025
Familial colorectal cancer: search for novel predisposition genes.
Article in Human genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundFamily history of colorectal cancer (CRC) and multiple primary CRCs in a single person may indicate inherited CRC predisposition.
methodsIn the present study, we performed whole exome/genome sequencing on germline DNA from at least two CRC cases in 19 families and from family members with a double primary CRC from seven additional families. We used a set of in silico predictions in combination with a STRING protein-protein interaction and pathway analysis to identify the most likely variants predisposing to CRC.
resultsWe identified Cell cycle/DNA repair and TGFβ signaling/Focal adhesion/Extracellular matrix organization pathways as highly significant protein-protein interaction networks. Variants in the APCDD1, CYBA, PTK7 and SRC genes were identified in more than one family, and they were shown to dysregulate basic cellular functions, potentially leading to cancer development. Most variants were private to a family, and each family had more than one candidate variant, suggesting a synergistic or polygenic mode of inheritance. This hypothesis, as well as validation of the identified variants and pathways and their functional consequences, need confirmation by other family-based studies.
conclusionsDifferent types of family-based analyses together with in silico predictions are helpful to identify candidate genes and pathways for CRC predisposition.
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