Evidence map›Paper›PMID 41469712›Full record

ArticleStem cell research & therapy2025

The treatment of acute tendon injury with small extracellular vesicles originating from TNFAIP6

Hengchen Liu, Aodan Zhang, Manyu Shi, Jingyao Zhang, Tingting Zhang, Wenjun Lu, Mingzhao Zhang, Zenan Zhang, Yang Wu, Yibo Miao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hengchen Liu *Department of Colorectal Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Provincial Clinical Research Center for Cancer, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, Zhejiang, China.
Aodan Zhang *Department of Pediatric Surgery, The Sixth Hospital Affiliated to Harbin Medical University, HarbinMedical University, Harbin, 150000, Heilongjiang, China.
Manyu Shi *Department of Pediatric Surgery, The Sixth Hospital Affiliated to Harbin Medical University, HarbinMedical University, Harbin, 150000, Heilongjiang, China.
Jingyao ZhangDepartment of 'A' Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310000, Zhejiang, China.
Tingting ZhangDepartment of Pediatric Surgery, The Sixth Hospital Affiliated to Harbin Medical University, HarbinMedical University, Harbin, 150000, Heilongjiang, China.
Wenjun LuDepartment of Pediatric Surgery, The Sixth Hospital Affiliated to Harbin Medical University, HarbinMedical University, Harbin, 150000, Heilongjiang, China.
Mingzhao ZhangDepartment of Pediatric Surgery, The Sixth Hospital Affiliated to Harbin Medical University, HarbinMedical University, Harbin, 150000, Heilongjiang, China.
Zenan ZhangDepartment of Pediatric Surgery, The Sixth Hospital Affiliated to Harbin Medical University, HarbinMedical University, Harbin, 150000, Heilongjiang, China.
Yang WuDepartment of Pediatric Surgery, The Sixth Hospital Affiliated to Harbin Medical University, HarbinMedical University, Harbin, 150000, Heilongjiang, China.
Yibo MiaoDepartment of Pediatric Surgery, The Sixth Hospital Affiliated to Harbin Medical University, HarbinMedical University, Harbin, 150000, Heilongjiang, China.
Shuyao WangDepartment of Pediatric Surgery, The Sixth Hospital Affiliated to Harbin Medical University, HarbinMedical University, Harbin, 150000, Heilongjiang, China.
Limin HouDepartment of Pediatric Surgery, The Sixth Hospital Affiliated to Harbin Medical University, HarbinMedical University, Harbin, 150000, Heilongjiang, China.
Qingbo CuiDepartment of Pediatric Surgery, The Sixth Hospital Affiliated to Harbin Medical University, HarbinMedical University, Harbin, 150000, Heilongjiang, China. cuiqingbocqb@163.com.
Zhaozhu LiDepartment of Pediatric Surgery, The Sixth Hospital Affiliated to Harbin Medical University, HarbinMedical University, Harbin, 150000, Heilongjiang, China. zhaozhu247@163.com.

Funding

National Natural Science Foundation of China 81871837Natural Science Foundation of Anhui Province 2308085QH259Natural Science Foundation of Zhejiang Province LQN25H170001Specialized Research Fund for the Doctoral Program of Higher Education of China 20132307110007
6 · The paper itself

Abstract

backgroundSmall extracellular vesicles originating from adipose-derived mesenchymal stromal cells (ADSC-sEVs) have excellent therapeutic value in acute tendon injury. However, their mechanism and effects have not been fully elucidated. This study aimed to identify the key subsets and mechanisms of action of ADSC-sEVs involved in the repair of complete tendon tear caused by acute injury.

methodsBased on our previous research demonstrating that ADSC-sEVs improve the quality of acute tendon injury repair, the present study utilized second-generation sequencing and bioinformatics to predict the key role of the TNFAIP6

resultsTNFAIP6

conclusionsOur findings enhance the current understanding of how TNFAIP6

Indexed as

Extracellular VesiclesMesenchymal Stem CellsMesenchymal Stem Cell TransplantationTendon InjuriesAnimalsCell Adhesion MoleculesCell MovementCell ProliferationHumansMaleMiceMicroRNAsCell Adhesion MoleculesMicroRNAsTNFAIP6 protein, humanAdipose-derived mesenchymal stromal cellsSmall extracellular vesiclesTendon healingTendon stem cellsTNFAIP6

Identifiers

PMID41469712
PMCPMC12866520

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.