Evidence map›Paper›PMID 41469687›Full record

ArticleTrials2025

Comparative evaluation of standardized imaging-guided contact selection for subthalamic deep brain stimulation in Parkinson's disease: study protocol for a randomized double-blind crossover trial.

G A Brandt, L Piotrowsky, J N Petry-Schmelzer, C van der Linden, C Schedlich-Teufer, V Visser-Vandewalle, T A Dembek, M T Barbe

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

G A BrandtDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. gregor.brandt@uk-koeln.de.
L PiotrowskyDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
J N Petry-SchmelzerDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
C van der LindenDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
C Schedlich-TeuferDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
V Visser-VandewalleDepartment of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
T A DembekDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
M T BarbeDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSubthalamic deep brain stimulation (STN-DBS) effectively treats motor symptoms in appropriately selected patients with Parkinson's disease, but individual responses vary. Despite modern directional leads allowing more precise stimulation, optimal contact selection strategies have not yet been standardized. This study compares a standardized imaging-guided contact selection protocol to conventional clinical programming.

methodsWe designed a monocentric, randomized, double-blind crossover trial enrolling 30 people with Parkinson's disease with bilateral directional STN-DBS. Participants will undergo both programming approaches: standardized imaging-guided contact selection targeting the dorsolateral STN and conventional contact selection through clinical test stimulations. Each configuration will be applied for 1 week. The primary outcome is patient preference after both treatments. Secondary outcomes include motor assessments (MDS-UPDRS III), accelerometric monitoring, and questionnaire-based quality of life measures (e.g., PDQ-39). DISCUSSION: This study addresses a critical gap in standardization of imaging-guided DBS programming. By using patient preference as the primary outcome, we aim to capture clinically meaningful differences that may not be detected with traditional motor scales. The crossover design balances statistical power with clinical feasibility in specialized care settings.

trial registrationDeutsches Register für Klinische Studien DRKS00034229. Registered on May 27, 2024.

Indexed as

Deep Brain StimulationParkinson DiseaseSubthalamic NucleusAgedCross-Over StudiesDouble-Blind MethodFemaleHumansMaleMiddle AgedPatient PreferenceQuality of LifeRandomized Controlled Trials as TopicTreatment OutcomeClinical trialsDeep brain stimulationImaging-guided programmingParkinson’s diseaseSubthalamic nucleus

Identifiers

PMID41469687
PMCPMC12849625

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.