ArticleBiomedical engineering online2025
Evaluation of the stiffness of the transplanted liver and spleen in recipients after liver transplantation on shear wave elastography.
Article in Biomedical engineering online, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLiver fibrosis after liver transplantation seriously affects graft survival. This study aimed to use shear wave elastography (SWE) to non-invasively evaluate the stiffness of the transplanted liver and spleen in liver transplant recipients.
methodsSeventy-one patients who were regularly reviewed in our hospital after liver transplantation (> 2 years) were enrolled and were divided into two groups: Group B (30 cases without splenomegaly before liver transplantation) and Group C (41 cases with splenomegaly before liver transplantation). Besides, we selected 35 normal controls as Group A. All patients underwent conventional ultrasound, SWE, and serum liver fibrosis markers exams to obtain the oblique diameter of right lobe of liver (ODRL), portal vein diameter (PVD), portal vein velocity (PVV), peak systolic velocity (PSV), splenic vein diameter (SVD), splenic length, splenic thickness, liver stiffness measurement (LSM), spleen stiffness measurement (SSM) and laboratory test results. Research the correlation between SWE parameters and serum liver fibrosis markers by Pearson linear analysis.
resultsThere was no difference in ODRL, PVD, PVV, and PSV among the three groups (all P > 0.05). Compared with Group A, hyaluronic acid (HA), laminin (LN), type III N-peptide collagen (PIIIP N-P), collagen type IV (IVC), and LSM were increased in Groups B and C (all P < 0.05) and were all higher in Group C than in Group B (all P < 0.05). Compared with Groups A and B, Group C was significantly higher in SVD, splenic length, splenic thickness, and SSM (all P < 0.05), whereas there was no difference in comparison of Group B with Group A (all P > 0.05). Pearson's correlation analysis showed that LSM and HA, LN, PIIIN-P, and IVC were positively correlated.
conclusionSWE is valuable to evaluate the stiffness of transplanted liver and spleen in recipients after liver transplantation, and preoperative splenomegaly is a factor influencing graft fibrosis after transplantation.
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