Evidence map›Paper›PMID 41469592›Full record

ArticleBMC public health2025

Generalized and COVID-19 related anxiety among Tanzanian adolescents with HIV and association with HIV outcomes during the COVID-19 pandemic.

Hellen N Siril, David Gitagno, Sylvia Kaaya, Matthew Caputo, Lisa R Hirschhorn, Tumaini Nyamhanga, Rachel Mtei, Charles Festo, Claudia Hawkins

Erratum issuedAbstract read
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Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Hellen N SirilDepartment of Psychiatry and Mental Health, Muhimbili University of Health and Allied Sciences, 9 United Nations Road, Upanga West, Dar es Salaam, 11103, Tanzania. neemasiril@gmail.com.
David GitagnoDepartment of Psychiatry and Mental Health, Muhimbili University of Health and Allied Sciences, 9 United Nations Road, Upanga West, Dar es Salaam, 11103, Tanzania.
Sylvia KaayaDepartment of Psychiatry and Mental Health, Muhimbili University of Health and Allied Sciences, 9 United Nations Road, Upanga West, Dar es Salaam, 11103, Tanzania.
Matthew CaputoRobert J Havey Institute of Global Health, Northwestern University Feinberg School of Medicine, 710 N Lake Shore Dr, Ste 800, Chicago, IL, 6061, USA.
Lisa R HirschhornRobert J Havey Institute of Global Health, Northwestern University Feinberg School of Medicine, 710 N Lake Shore Dr, Ste 800, Chicago, IL, 6061, USA.
Tumaini NyamhangaDepartment of Development Studies, Muhimbili University of Health and Allied Sciences, 9 United Nations Road, Dar es Salaam, Upanga West, 11103, Tanzania.
Rachel MteiDepartment of Psychiatry and Mental Health, Muhimbili University of Health and Allied Sciences, 9 United Nations Road, Upanga West, Dar es Salaam, 11103, Tanzania.
Charles FestoDepartment of HIV Care and Treatment Programs, Management and Development for Health (MDH), 802 Mwai Kibaki Rd, Mikocheni, Dar es Salaam, Tanzania.
Claudia HawkinsRobert J Havey Institute of Global Health, Northwestern University Feinberg School of Medicine, 710 N Lake Shore Dr, Ste 800, Chicago, IL, 6061, USA.

Funding

Building capacity for patient-centered outcomes research to improve the quality and impact of HIV care in TanzaniaD43TW010946 · FIC · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HAWKINS, CLAUDIA A, HIRSCHHORN, LISA · 2019 to 2023
$1.7M
FIC NIH HHS D43 TW010946NIH HHS D43TW010946-03S1
6 · The paper itself

Abstract

The COVID-19 pandemic resulted in significant disruptions to HIV services globally. The impact of COVID-19 on mental wellbeing and HIV outcomes among adolescents with HIV (AWH) in Tanzania is unknown. We assessed the burden of generalized and COVID-19 related anxiety and associations with adherence to HIV care and treatment and viral load suppression (VLS) among AWH during the peak of the COVID-19 pandemic in Tanzania.

methodsThis cross-sectional study was conducted among AWH aged 15-19 years attending 10 clinics in Dar es Salaam from April-December 2022. Trained RAs administered a questionnaire to study participants which included questions on Generalized Anxiety Disorder (GAD), COVID-19 related anxiety, and other psychosocial and physical health and support measures such as self-management and quality of physical health. HIV clinic visit adherence, viral load and sociodemographic data were abstracted from patient health records. Multivariable quasibinomial and logistic regression models examined associations of Generalized and COVID-19 related anxiety with visit adherence (attending all scheduled visits (+/- 3 days) for 12 months prior to September 2019) and HIV virologic suppression (HIV VL < 50 copies/mL), respectively. Data were analyzed using R software.

resultsFive hundred sixty seven AWH (48% male, median time on ART 125 (interquartile range (IQR) 79 months)) were included in this analysis. Over half (53%) attended at least 75% of their scheduled clinic visits, and 78% were HIV virologically suppressed (< 50 copies/mL). The median GAD and COVID-19-related anxiety scores were 1 [IQR: 4], and 25 [IQR: 31], respectively. Only 2% scored moderate-severe generalized anxiety (score 10-21). We found no significant associations between COVID-19 related anxiety [adjusted odds ratio (AOR) = 1.00 (95% CI 0.90, 1.00)] or GAD [AOR = 1.03 (0.99, 1.07)] and visit adherence. Higher GAD was inversely associated with VLS [AOR: 0.90 (95% CI 0.81, 0.99]. Female gender [AOR = 1.67 (95% CI 1.05, 2.66)], higher quality of physical life [AOR 1.17 (95% CI 1.04, 1.32)] and living with parents [AOR = 1.61 (1.00, 2.57)] were significantly associated with VLS.

conclusionsLow levels of generalized and COVID-19 related anxiety were reported among Tanzanian AWH. Scaling up integrated screening and management of GAD into HIV care for AWH could improve VLS among this population.

Indexed as

AnxietyCOVID-19HIV InfectionsAdolescentCross-Sectional StudiesFemaleHumansMaleSurveys and QuestionnairesTanzaniaViral LoadYoung AdultAdolescentsAnxietyCOVID-19HIVTanzania

Identifiers

PMID41469592
PMCPMC12754932

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.