ArticleNPJ biofilms and microbiomes2025
Microbiota-derived indole-3-acetic acid alleviates rumen epithelial barrier dysfunction during the peripartum period through AhR signaling.
Article in NPJ biofilms and microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Metabolic shifts driven by host-microbial interactions.The FEBS journal · 2026Review
- Microbial and Metabolic Dysbiosis in Ruminal Acidosis: Mechanisms, Host Responses, and Microbiota-Targeted Mitigation Strategies.Microorganisms · 2026Review
- Article
- Microbial landscapes in dairy cow diseases: from localized dysbiosis to inter-organ axes.NPJ biofilms and microbiomes · 2026Review
- Rumen-host crosstalk: an amplifier of systemic pathology in heat-stressed ruminants.Frontiers in microbiology · 2026Review
- Mechanisms by which tryptophan metabolites enhance intestinal barrier function to prevent necrotizing enterocolitis in preterm infants.Frontiers in immunology · 2026Review
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Authors and funding
11 authors.
Funding
Abstract
Peripartum dairy cows are highly susceptible to metabolic disorders, with ketosis being the most prevalent postpartum disease associated with rumen microbial dysbiosis and systemic inflammation. However, the mechanisms by which microbial alterations compromise rumen epithelial integrity remain poorly understood. Using peripartum cows with ketosis as a model, we demonstrated that perturbations of rumen microbiota disrupt tryptophan metabolism, resulting in pronounced depletion of indole-3-acetic acid (IAA). The loss of IAA-producing taxa (Lactobacillus and Bifidobacterium) contributed to reduced IAA levels and epithelial barrier dysfunction, whereas enrichment of proinflammatory taxa (Candidatus Saccharimonas and Mycoplasma) was associated with exacerbated epithelial inflammation. In vitro, IAA supplementation activated the AhR/IL-22 signaling pathway, promoting bovine rumen epithelial cells (BRECs) regeneration and restoring barrier integrity. These findings identify the microbiota-IAA-AhR/IL-22 axis as a key regulator of rumen epithelial homeostasis and suggest that targeting this pathway represents a promising strategy to prevent metabolic disorders in dairy cows.
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Registered trials
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