Evidence map›Paper›PMID 41469444›Full record

ArticleNature neuroscience2026

Infinite hidden Markov models can dissect the complexities of learning.

Sebastian A Bruijns, International Brain Laboratory, Kcénia Bougrova, Inês C Laranjeira, Petrina Y P Lau, Guido T Meijer, Nathaniel J Miska, Jean-Paul Noel, Alejandro Pan-Vazquez, Noam Roth and 3 more

Abstract read
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sebastian A BruijnsMax Planck Institute for Biological Cybernetics, Tübingen, Germany. sabruijns@gmail.com.ORCID http://orcid.org/0000-0002-0854-9159
International Brain Laboratory
Kcénia BougrovaChampalimaud Foundation, Lisbon, Portugal.
Inês C LaranjeiraChampalimaud Foundation, Lisbon, Portugal.
Petrina Y P LauUniversity College London, London, United Kingdom.
Guido T MeijerChampalimaud Foundation, Lisbon, Portugal.ORCID http://orcid.org/0000-0002-7473-0482
Nathaniel J MiskaSainsbury Wellcome Centre, University College London, London, United Kingdom.
Jean-Paul NoelUniversity of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-5297-3363
Alejandro Pan-VazquezPrinceton University, Princeton, NJ, USA.
Noam RothUniversity of Washington, Seattle, WA, USA.
Karolina Z SochaUniversity College London, London, United Kingdom.
Anne E UraiLeiden University, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-5270-6513
Peter DayanMax Planck Institute for Biological Cybernetics, Tübingen, Germany.ORCID http://orcid.org/0000-0003-3476-1839

Funding

Simons Foundation 552343Wellcome TrustWellcome Trust 216324
6 · The paper itself

Abstract

Learning the contingencies of a task is difficult. Individuals learn in an idiosyncratic manner, revising their approach multiple times as they explore and adapt. Quantitative characterization of these learning curves requires a model that can capture both new behaviors and slow changes in existing ones. Here we suggest a dynamic infinite hidden semi-Markov model, whose latent states are associated with specific components of behavior. This model can describe new behaviors by introducing new states and capture more modest adaptations through dynamics in existing states. We tested the model by fitting it to behavioral data of >100 mice learning a contrast-detection task. Although animals showed large interindividual differences while learning this task, most mice progressed through three stages of task understanding, new behavior often arose at session onset, and early response biases did not predict later ones. We thus provide a new tool for comprehensively capturing behavior during learning.

Indexed as

LearningMarkov ChainsAnimalsBehavior, AnimalHidden Markov ModelsMaleMiceMice, Inbred C57BL

Identifiers

PMID41469444
PMCPMC12779568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.