Evidence map›Paper›PMID 41469347›Full record

ArticleProblemy radiatsiinoi medytsyny ta radiobiolohii2025

INDIVIDUAL THYROID DOSE ESTIMATES FOR THE GENOMIC STUDY OF FOLLICULAR CARCINOMAS AND ADENOMAS IN PARTICIPANTS OF THE CHORNOBYL TISSUE BANK.

S V Masiuk, M I Chepurny, V B Buderatska, O M Ivanova, Z N Boiko, N S Zhadan, H V Chornovol, M Yu Bolgov, V M Shpak, M D Tronko and 7 more

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In one paragraph

Article in Problemy radiatsiinoi medytsyny ta radiobiolohii, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

S V MasiukState Institution «National Scientific Center of Radiation Medicine, Hematology and Oncology» of the National Academy of Medical Sciences of Ukraine, 53 Yuriia Illienka St., Kyiv 04050, Ukraine.
M I ChepurnyState Institution «National Scientific Center of Radiation Medicine, Hematology and Oncology» of the National Academy of Medical Sciences of Ukraine, 53 Yuriia Illienka St., Kyiv 04050, Ukraine.
V B BuderatskaState Institution «National Scientific Center of Radiation Medicine, Hematology and Oncology» of the National Academy of Medical Sciences of Ukraine, 53 Yuriia Illienka St., Kyiv 04050, Ukraine.
O M IvanovaState Institution «National Scientific Center of Radiation Medicine, Hematology and Oncology» of the National Academy of Medical Sciences of Ukraine, 53 Yuriia Illienka St., Kyiv 04050, Ukraine.
Z N BoikoState Institution «National Scientific Center of Radiation Medicine, Hematology and Oncology» of the National Academy of Medical Sciences of Ukraine, 53 Yuriia Illienka St., Kyiv 04050, Ukraine.
N S ZhadanState Institution «National Scientific Center of Radiation Medicine, Hematology and Oncology» of the National Academy of Medical Sciences of Ukraine, 53 Yuriia Illienka St., Kyiv 04050, Ukraine.
H V ChornovolState Institution «National Scientific Center of Radiation Medicine, Hematology and Oncology» of the National Academy of Medical Sciences of Ukraine, 53 Yuriia Illienka St., Kyiv 04050, Ukraine.
M Yu BolgovState Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine», 69 Vyshhorodska St., Kyiv 04114, Ukraine.
V M ShpakState Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine», 69 Vyshhorodska St., Kyiv 04114, Ukraine.
M D TronkoState Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine», 69 Vyshhorodska St., Kyiv 04114, Ukraine.
T I BogdanovaState Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine», 69 Vyshhorodska St., Kyiv 04114, Ukraine.
D KaryadiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 9609 Medical Center Drive, Bethesda, MD 20892, USA.
V VijDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 9609 Medical Center Drive, Bethesda, MD 20892, USA.
E K CahoonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 9609 Medical Center Drive, Bethesda, MD 20892, USA.
S J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 9609 Medical Center Drive, Bethesda, MD 20892, USA.
L M MortonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 9609 Medical Center Drive, Bethesda, MD 20892, USA.
V DrozdovitchDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 9609 Medical Center Drive, Bethesda, MD 20892, USA.

Funding

PROCESS DEVELOPMENT OF TELACEBEC FOR TUBERCULOSIS75N95024D00012 · NIDA · MIDWEST RESEARCH INSTITUTE · PI SLADE, DESMOND · 2024 to 2025
$742k
CLC NIH HHS 75N90024D00012Intramural NIH HHS Z99 CA999999NIDA NIH HHS 75N95024D00012NIH HHS 75N98024D00012
6 · The paper itself

Abstract

objectiveAssessment of thyroid doses among participants of the Chornobyl Tissue Bank (CTB) enrolled in the study of the genomic landscape of thyroid follicular carcinomas and follicular adenomas, using updated methodologies and data on residential history and dietary patterns collected during the study through personal dosimetry interviews. MATERIALS AND

methodsThis study presents an assessment of thyroid doses in 140 participants of the Chornobyl Tissue Bank (CTB) with pathologically confirmed diagnoses of follicular adenoma and follicular thyroid carcinoma.Thyroid doses from 131I intake were estimated using the substantially revised 'Thyroid Dosimetry System 2020 for Ukraine' (TDU20). In addition, the data on residential and dietary history have been obtained through personal interviews with 85 individuals for whom dosimetryrelated data were limited. Radiation doses to the thyroid were also estimated for the following minor exposure pathways: (a) intake of short lived radionuclides (132Te+132I and 133I) via inhalation and ingestion; (b) external irradiation from radionuclides deposited on the ground; and (c) ingestion of 134Cs and 137Cs with contaminated foodstuffs.

resultsThe arithmetic mean of thyroid doses estimated in this study from all exposure pathways combined was 445 mGy, while the median dose was 71 mGy. Among study participants, a broad range of thyroid doses was observed, from 0.23 mGy to 14 Gy. The major exposure pathway was 131I intake, which accounted for a median contribution of 92 % to the thyroid dose. Among individuals who were interviewed in the study, thyroid doses from 131I intake that were calculated using TDU20 and individual questionnaire data were lower than doses that did not include the interview data: 105 mGy vs. 150 mGy for the arithmetic mean and 46 mGy vs. 98 mGy for the median, respectively.Uncertainties in dose estimates from 131I intake were characterized using the geometric standard deviation of 1,000 individual stochastic dose realizations. As a result, the geometric standard deviation ranged from 1.3 to 6.1, with an overall arithmetic mean of 3.1 and a median of 3.3 across all study participants.

conclusionsThis study demonstrated that the use of individual questionnaire data in dose assessment for participants who completed personal dosimetric interviews had an impact on the estimated thyroid doses. In conducting specialized studies aimed at identifying potential associations between thyroid dose and key demographic, clinical, pathological, and moleculargenetic indicators, it is valuable to carry out personal dosimetric interviews to obtain detailed residential and dietary histories of study participants. Incorporating such information allows for more realistic individual dose estimates.

Indexed as

Adenocarcinoma, FollicularAdenomaChernobyl Nuclear AccidentNeoplasms, Radiation-InducedRadiation ExposureThyroid GlandThyroid NeoplasmsAdultAgedCesium RadioisotopesFemaleGenomicsHumansIodine RadioisotopesMaleMiddle AgedCesium-137Cesium RadioisotopesIodine-131Iodine RadioisotopesChernobylChornobyl Tissue Bankdosimetry interviewradiation dosethyroid

Identifiers

PMID41469347
PMCPMC12777514

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.