Evidence map›Paper›PMID 41469160›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2026

Biologically Individualized Radiotherapy Based on PET: A Novel Approach to Treatment Optimization of Head and Neck Cancer.

Marta Lazzeroni, Ana Ureba, Henning Schäfer, Nils H Nicolay, Alexander Rühle, Dimos Baltas, Alexandru Dasu, Philipp T Meyer, Michael Mix, Iuliana Toma-Dasu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marta LazzeroniDepartment of Physics, Stockholm University, Stockholm, Sweden; marta.lazzeroni@fysik.su.se.
Ana UrebaDepartment of Physics, Stockholm University, Stockholm, Sweden.
Henning SchäferDepartment of Radiation Oncology, Medical Center, Medical Faculty Freiburg, German Cancer Consortium Partner Site Freiburg, Freiburg,Germany.
Nils H NicolayDepartment of Radiation Oncology, Medical Center, Medical Faculty Freiburg, German Cancer Consortium Partner Site Freiburg, Freiburg,Germany.
Alexander RühleDepartment of Radiation Oncology, Medical Center, Medical Faculty Freiburg, German Cancer Consortium Partner Site Freiburg, Freiburg,Germany.
Dimos BaltasDepartment of Radiation Oncology, Medical Center, Medical Faculty Freiburg, German Cancer Consortium Partner Site Freiburg, Freiburg,Germany.
Alexandru DasuSkandion Clinic, Uppsala, Sweden.
Philipp T MeyerDepartment of Nuclear Medicine, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
Michael MixDepartment of Nuclear Medicine, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
Iuliana Toma-DasuDepartment of Physics, Stockholm University, Stockholm, Sweden.
Anca L GrosuDepartment of Radiation Oncology, Medical Center, Medical Faculty Freiburg, German Cancer Consortium Partner Site Freiburg, Freiburg,Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current radiotherapy for malignant tumors often adopts a "one-size-fits-all" approach, prescribing the same irradiation dose for patients with similar clinical indications. However, advancements in functional imaging allow for biologically individualized strategies, with dose distribution tailored to the specific tumor biology. This study proposes a novel approach to biologically individualized radiotherapy, exploiting the synergistic combination of the tumor clonogenic cell information from [

Indexed as

Head and Neck NeoplasmsPositron-Emission TomographyPrecision MedicineAdultAgedFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedMisonidazoleRadiotherapy DosageRadiotherapy Planning, Computer-AssistedFluorodeoxyglucose F18fluoromisonidazoleMisonidazolebiologically individualized radiotherapyclonogenic cell densitydual-tracer PEThead and neck squamous cell carcinomatumor hypoxia

Identifiers

PMID41469160
PMCPMC12955532

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.