Evidence map›Paper›PMID 41469158›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2026

BANTAM-01: A Multicenter, Open-Label, First-in-Human Phase 1 Dose Escalation and Expansion Study of

Jorrit Tjeertes, Miroslav Dostalek, Charles Glaus, Vinita Gupta, Daneng Li, Antje Nestler, Vasiliki Pelekanou, Joerg Pinkert, Ida Ratih, Eric Smith and 6 more

Abstract readMulticenter StudyClinical Trial, Phase I
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Glypican-3-targeted bioconjugates for hepatocellular carcinoma: design, engineering, and translational applications.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jorrit TjeertesBayer AG, Basel, Switzerland.
Miroslav DostalekBayer AG, Basel, Switzerland.
Charles GlausBayer Research and Innovation Center, Bayer US, Cambridge, Massachusetts.
Vinita GuptaBayer Research and Innovation Center, Bayer US, Cambridge, Massachusetts.
Daneng LiCity of Hope Comprehensive Cancer Center, Duarte, California.
Antje NestlerBayer AG, Berlin, Germany.
Vasiliki PelekanouBayer Research and Innovation Center, Bayer US, Cambridge, Massachusetts.
Joerg PinkertBayer AG, Berlin, Germany.
Ida RatihBayer PLC, Reading, Berkshire, United Kingdom.
Eric SmithBayer Research and Innovation Center, Bayer US, Cambridge, Massachusetts.
Shyamal SubramanyamBayer US, Whippany, New Jersey.
Arndt VogelToronto General Hospital and Princess Margaret Cancer Center, Toronto, Ontario, Canada.
Katrina WalkerBayer PLC, Reading, Berkshire, United Kingdom.
Andrea Wilson WoodsBlue Faery, Birmingham, Alabama; and.
Stefan ZimmermannBayer Research and Innovation Center, Bayer US, Cambridge, Massachusetts.
Henrik JungerBayer AG, Berlin, Germany; henrik.junger@bayer.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the increasing availability of systemic therapies to treat advanced hepatocellular carcinoma (HCC), the prognosis remains poor. There is therefore an unmet need for targeted therapies with a novel mode of action that are more tolerable and effective than current treatment options. Targeted α-therapies selectively deliver high-energy α-particle-emitting radionuclides to tumor-associated cell surface antigens, inducing difficult-to-repair DNA double-stranded breaks, while limiting damage to surrounding tissue. Elevated expression of the oncofetal cell surface heparan sulfate proteoglycan, glypican-3 (GPC3), is seen in more than 70% of HCCs and is a negative prognostic indicator. BAY 3547926 (

Indexed as

ActiniumCarcinoma, HepatocellularGlypicansLiver NeoplasmsAdultClinical Trials, Phase I as TopicDose-Response Relationship, DrugFemaleHumansMaleMiddle AgedActiniumGlypicansGPC3 protein, human225AcBANTAM-01GPC3hepatocellular carcinomatargeted α-therapy

Identifiers

PMID41469158
PMCPMC12955502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.