Evidence map›Paper›PMID 41469154›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2026

Influence of Subcellular Localization on the Cytotoxicity of Targeted α-Therapy.

Hwan Lee, Swarbhanu Sarkar, Kexiang Xu, Paul Martorano, Jonathan Pham, Peter Sang Uk Park, A Paden King, Hsiaoju S Lee, David A Mankoff, Daniel A Pryma and 1 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Current status of radionuclide therapy targeting PARP in cancer: challenges and prospects.European journal of nuclear medicine and molecular imaging · 2026
    Review
  2. Monte Carlo microdosimetry ofEJNMMI physics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hwan LeeDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Swarbhanu SarkarDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Kexiang XuDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Paul MartoranoDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Jonathan PhamDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Peter Sang Uk ParkDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
A Paden KingDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Hsiaoju S LeeDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
David A MankoffDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Daniel A PrymaDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Mark A SellmyerDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; mark.sellmyer@pennmedicine.upenn.edu.

Funding

RESEARCH TRACK RADIOLOGY RESIDENCYT32EB004311 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Terence P Gade, Misun Hwang · 2005 to 2026
$4.5M
Regulation of eDHFR-tagged proteins with trimethoprim PROTACsR01GM150804 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Mark A Sellmyer · 2023 to 2026
$2.4M
Next generation tools for imaging bacterial infection and its relationship to the immune systemDP5OD026386 · OD · UNIVERSITY OF PENNSYLVANIA · PI SELLMYER, MARK A · 2018 to 2022
$2.0M
NIBIB NIH HHS T32 EB004311NIGMS NIH HHS R01 GM150804NIH HHS DP5 OD026386
6 · The paper itself

Abstract

Targeted α-therapy (TAT) is a promising approach for radiopharmaceutical therapy with various molecular targets, but uncertainty exists as to whether the subcellular location of a target influences its cytotoxicity. We used a model system that provides a subcellular "zip code" for TAT to determine whether localizing α-emitters closer to the DNA increases their cytotoxic effect.

Indexed as

Alpha ParticlesAstatineMolecular Targeted TherapyAnimalsCell Line, TumorFemaleHumansMiceRadiopharmaceuticalsTetrahydrofolate DehydrogenaseTissue DistributionAstatineAstatine-211RadiopharmaceuticalsTetrahydrofolate Dehydrogenasecytotoxicitysubcellular localizationtargeted α-therapy

Identifiers

PMID41469154
PMCPMC12955540

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.