Evidence map›Paper›PMID 41469059›Full record

ArticleBMJ open2025

Effects of different folic acid supplementation doses on subsequent pregnancy outcomes in women with a history of pregnancy loss: study protocol for a multicentre randomised controlled trial.

Cai Liu, Zhuhua Cai, Lirong Du, Zhou Fang, Hongjun Yang, Haiyan Wu, Qun Li, Aiqin Yan, Luming Chen, Ran An and 4 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Cai LiuDepartment of Reproductive medicine, Lanzhou University Second Hospital, Lanzhou, China.ORCID http://orcid.org/0009-0004-4099-3796
Zhuhua CaiDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, China.ORCID http://orcid.org/0009-0005-3566-8697
Lirong DuHebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China.
Zhou FangReproductive Medical Center, Shandong University of Traditional Chinese Medicine, Jinan, China.
Hongjun YangDepartment of Reproductive Medicine, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, China.
Haiyan WuDepartment of Gynaecology and Obstetrics, Pingliang Second People's Hospital, Pingliang, China.
Qun LiDepartment of Obstetrics, Tianshui First People's Hospital, Tianshui, China.
Aiqin YanDepartment of Reproductive Medicine, Zhangye Second People's Hospital, Zhangye, China.
Luming ChenDepartment of Gynaecology and Obstetrics, Longxi County Hospital of Traditional Chinese Medicine, Dingxi, China.
Ran AnDepartment of Obstetrics and Gynaecology, Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Qiaohua HeDepartment of Reproductive Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
Xueqin ZhangDepartment of Obstetrics and Gynecology, Longyang District Maternal and Child Health Hospital of Baoshan City, Baoshan, China.
Yuefang RenDepartment of Obstetrics and Gynaecology, Longyang District Maternal and Child Health Hospital of Baoshan City, Baoshan, China.
Fang WangDepartment of Reproductive medicine, Lanzhou University Second Hospital, Lanzhou, China ery_fwang@lzu.edu.cn.ORCID http://orcid.org/0000-0001-7895-374X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFolic acid is crucial for fetal development, particularly during early pregnancy. Studies suggest that high folic acid intake (≥800 µg/day) may be associated with a reduced risk of miscarriage. However, the impact of an 800 µg dose on pregnancy outcomes in women with prior pregnancy loss currently remains unclear. METHODS AND ANALYSIS: We will conduct a multi-centre randomised controlled study comparing 800 µg and 400 µg in women with previous pregnancy loss. The primary outcome is live birth. Secondary outcomes include early pregnancy loss, ongoing pregnancy at 24 gestation weeks, homocysteine (Hcy) reduction, maternal and perinatal outcomes. We plan to recruit 1116 women (558 women per group). Data analysis will follow the intention-to-treat principle and per-protocol. Subgroup analysis will be conducted based on Hcy levels, previous pregnancy losses and body mass index. TRIAL REGISTRATION NUMBER: ChiCTR2500100255.

Indexed as

Abortion, SpontaneousDietary SupplementsFolic AcidPregnancy OutcomeVitamin B ComplexAdultFemaleHomocysteineHumansMulticenter Studies as TopicPregnancyRandomized Controlled Trials as TopicFolic AcidHomocysteineVitamin B ComplexPregnancyRandomized Controlled TrialTreatment Outcome

Identifiers

PMID41469059
PMCPMC12750762

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.