ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Calculation of pulmonary capillary wedge pressure including left atrial function is superior to morphology alone and accurately identifies elevated filling pressures in left heart disease.
Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Usefulness of Strain Echocardiography in Heart Failure with Preserved Ejection Fraction.Journal of clinical medicine · 2026Review
- Feasibility of quantitative pulmonary function imaging in real-world cardiovascular magnetic resonance.The international journal of cardiovascular imaging · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRight heart catheterization (RHC) with pulmonary capillary wedge pressure (PCWP) assessment is the reference standard for diagnosis of heart failure with preserved ejection fraction (HFpEF), but remains largely underused. Different approaches for non-invasive PCWP calculation have been proposed. However, as left atrial strain (LA Es) and end-systolic volume index (ESVi) emerge as key criteria in HFpEF, we sought to investigate them for PCWP calculation.
methodsThe derivation population consisted of patients referred to RHC and cardiovascular magnetic resonance (CMR) imaging who were enrolled in a prospective monocentric registry. Patients were classified by RHC according to current guideline recommendations. The external validation population consisted of patients included in the HFpEF-Stress trial who underwent exercise-stress RHC and CMR with follow-up after 4 years for hospitalized cardiovascular events. Performance of strain-derived PCWP was compared to a published LA volume (LAV) and left ventricular mass (LVM) derived method.
resultsThe derivation population consisted of n = 209 patients, n = 123 underwent exercise-stress RHC (n = 55 without pulmonary hypertension [PH], n = 72 pre-capillary, n = 27 combined post- and pre-capillary pulmonary hypertension [CpcPH], n = 15 isolated post-capillary pulmonary hypertension [IpcPH], n = 34 exercise, and n = 6 unclassified PH). Linear regression models identified the following formulae for functional PCWPrest 10.304 - 0.095 * Es + 0.098 * ESVi and functional PCWPstress 24.666 - 0.251 * Es + 0.056 * ESVi calculation. The validation population consisted of n = 74 patients (n = 15 without, n = 5 pre-capillary, n = 8 CpcPH, n = 10 IpcPH, and n = 32 exercise PH with n = 4 remaining unclassified). Functional PCWPrest (11.8) and RHC-derived PCWPrest (11 mmHg) were statistically similar (p = 0.285) and showed moderate correlation (r = 0.53, p < 0.001). Functional PCWPrest (area under the curve [AUC] 0.80) and PCWPstress (AUC 0.85) accurately identified HFpEF patients, were superior to LAV/LVM-based PCWP (AUC 0.67, p ≤ 0.002) and showed prognostic implications (hazard ratio 1.37 (1.16-1.62) and 1.29 (1.14-1.46), p < 0.001).
conclusionFunctional PCWP may aid in the identification of post-capillary involvement in PH and HFpEF superiorly compared to morphology-derived PCWP and shows prognostic implications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.