Evidence map›Paper›PMID 41468912›Full record

ArticleNucleic acids research2026

CircTarget: a comprehensive database of circRNA-target RNA interactions across multiple cell types.

Hongmei Zhang, Yuyang Zhang, Peng Li, Zhen Yuan, Wanglong Liu, Jinyue Zhang, Ruitian Li, Chen Lu, Ping Zhu, Yuanchao Xue

Abstract read
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Overview of circular RNA databases and other resources.Nature reviews. Molecular cell biology · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hongmei ZhangGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510100, China.
Yuyang ZhangDivision of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.
Peng LiState Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Zhen YuanState Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Wanglong LiuSchool of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
Jinyue ZhangState Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Ruitian LiSchool of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
Chen LuSchool of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
Ping ZhuGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510100, China.
Yuanchao XueState Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0002-8113-2333

Funding

Beijing Municipal Natural Science Foundation Z220011Chinese Academy of Sciences XDB37000000National Key Research and Development Program of China 2022YFA1303300National Natural Science Foundation of China 32025008National Natural Science Foundation of China 32130064National Natural Science Foundation of China 32300457National Natural Science Foundation of China 32470610
6 · The paper itself

Abstract

Circular RNAs (circRNAs) are stable, widespread regulatory molecules produced primarily by back-splicing of pre-mRNAs, with critical roles in gene regulation and disease pathogenesis. While significant progress has been made in circRNA identification, their targets remain largely unexplored. To address this, we present CircTarget, the first comprehensive database of experimentally supported circRNA-target RNA interactions mapped at single-nucleotide resolution. By analyzing RNA-RNA interactome data from multiple crosslinking methods across 13 cell lines and hippocampal tissues from human and mouse, we identified 132 517 high-confidence circRNA-target RNA interactions. Each entry in CircTarget is richly annotated, including circRNA basic information, disease associations, interaction regions, supporting chimeric read counts, predicted hybrid duplex structures, and disease-linked variants from GWAS Catalog, ClinVar, and ICGC databases. CircTarget provides a valuable resource for deciphering circRNA functions and is freely accessible at https://circtarget.cn.

Indexed as

Databases, GeneticDatabases, Nucleic AcidRNARNA, CircularAnimalsCell LineHippocampusHumansMiceRNARNA, Circular

Identifiers

PMID41468912
PMCPMC12807748

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.