ArticleCell2026
Neuronal calcium spikes enable vector inversion in the Drosophila brain.
Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Central complex representations of self-movement are sufficient to compute wind direction in flight.Science advances · 2026Article
- A framework for constructing insect steering circuits.PLoS computational biology · 2026Article
- Convergence-divergence circuits for multimodal integration of innate and learned opponent valences.Frontiers in systems neuroscience · 2026Article
- Spatiotemporal computations in the insect celestial compass.Nature communications · 2025Article
- Neural circuits for goal-directed navigation across species.Trends in neurosciences · 2024Review
- Continuous integration of heading and goal directions guides steering.bioRxiv : the preprint server for biology · 2024Article
- Wind gates olfaction-driven search states in free flight.Current biology : CB · 2024Article
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Abstract
A typical neuron signals to downstream cells when it is depolarized and fires sodium spikes. Some neurons, however, also fire calcium spikes when hyperpolarized. The function of such bidirectional signaling remains unclear in most circuits. Here, we show how a neuron class that participates in vector computation in the fly central complex employs hyperpolarization-elicited calcium spikes to invert two-dimensional mathematical vectors. By switching from firing sodium to calcium spikes, these neurons implement a ∼180° realignment between the vector encoded in the neuronal population and the fly's internal compass signal, thus inverting the vector. We show that calcium spikes rely on the T-type calcium channel Ca-α1T and argue via analytical and experimental approaches that these spikes enable vector computations in portions of angular space that would otherwise be inaccessible. These results reveal a seamless interaction between molecular, cellular, and circuit properties for implementing vector mathematics in the brain.
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