Evidence map›Paper›PMID 41468544›Full record

ArticleMicrobiology spectrum2026

Exacerbated salmonellosis in poly(ADP-ribose) polymerase 14-deficient mice.

Madhukar Vedantham, Lauri Polari, Tiia Rissanen, Arto Tapio Pulliainen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Madhukar VedanthamInstitute of Biomedicine, University of Turku, Turku, Finland.
Lauri PolariCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Tiia RissanenDepartment of Biostatistics, University of Turku, Turku, Finland.
Arto Tapio PulliainenInstitute of Biomedicine, University of Turku, Turku, Finland.ORCID 0000-0002-9361-8963

Funding

Novo Nordisk Fonden NNF23OC0087039Research Council of Finland (AKA) 295296, 329252Suomen Kulttuurirahasto 00231206Wellcome Trust 081781
6 · The paper itself

Abstract

IMPORTANCE: Eukaryotic cells rely on dynamic cell-signaling mechanisms to mount responses to external perturbations, such as an invading bacterial pathogen. The PARP protein family is a group of enzymes catalyzing a protein post-translational modification known as ADP-ribosylation. PARP1, the founding member, has received considerable research interest, in particular in cancer. However, recent data imply that PARP1 and, in particular, the other PARPs have regulatory functions in inflammatory responses. Yet, the mechanistic basis and, more importantly, the physiological relevance have largely remained elusive. Our study with the systemic Parp14-deficient mice provides compelling

Indexed as

Poly(ADP-ribose) PolymerasesSalmonella InfectionsSalmonella typhimuriumAnimalsDisease Models, AnimalEpithelial CellsIntestinal MucosaMacrophagesMiceMice, Inbred C57BLMice, KnockoutTh17 CellsPoly(ADP-ribose) PolymerasesgastroenteritisinfectioninflammationParp14Salmonella

Identifiers

PMID41468544
PMCPMC12889102

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.