Evidence map›Paper›PMID 41468521›Full record

ArticleJournal of the American Chemical Society2026

Fast, Bright, and Reversible Fluorescent Labeling of Rhodamine-Binding Proteins.

Julian Kompa, Lars J Dornfeld, Nicola Porzberg, Soohyen Jang, Silja Zedlitz, Simon H Lilje, Claudia Catapano, David Jocher, Lukas Merk, Carsten Hoege and 8 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Wash-Free Multi-Target Super-Resolution Microscopy With Photocaged DNA Labels.Angewandte Chemie (International ed. in English) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Julian KompaDepartment of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg 69120, Germany.ORCID 0000-0002-4479-5429
Lars J DornfeldDepartment of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg 69120, Germany.
Nicola PorzbergDepartment of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg 69120, Germany.ORCID 0009-0005-1830-2431
Soohyen JangInstitute of Physical and Theoretical Chemistry, Johann Wolfgang Goethe University, Frankfurt Am Main 60325, Germany.
Silja ZedlitzDepartment of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg 69120, Germany.
Simon H LiljeDepartment of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg 69120, Germany.
Claudia CatapanoInstitute of Physical and Theoretical Chemistry, Johann Wolfgang Goethe University, Frankfurt Am Main 60325, Germany.
David JocherDepartment of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg 69120, Germany.
Lukas MerkDepartment of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg 69120, Germany.ORCID 0009-0000-7187-1055
Carsten HoegeMax Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany.
Runyu MaoDepartment of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg 69120, Germany.
Jonas WilhelmDepartment of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg 69120, Germany.ORCID 0000-0003-1743-2726
Marina S DietzInstitute of Physical and Theoretical Chemistry, Johann Wolfgang Goethe University, Frankfurt Am Main 60325, Germany.ORCID 0000-0003-0504-1824
Miroslaw TarnawskiProtein Expression and Characterization Facility, Max Planck Institute for Medical Research, Heidelberg 69120, Germany.
Julien HiblotDepartment of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg 69120, Germany.
Anthony A HymanMax Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany.
Mike HeilemannInstitute of Physical and Theoretical Chemistry, Johann Wolfgang Goethe University, Frankfurt Am Main 60325, Germany.
Kai JohnssonDepartment of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg 69120, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rhodamine dyes conjugated to targeting ligands can yield exceptionally bright fluorescent probes for live-cell imaging. However, the limited permeability of such rhodamine derivatives restricts their broader applications, particularly

Indexed as

Fluorescent DyesRhodaminesAnimalsCaenorhabditis elegansHumansZebrafishFluorescent DyesRhodamines

Identifiers

PMID41468521
PMCPMC12814168

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.