ArticlePloS one2025
Prevalence and associating factors for iatrogenic gliosis-like changes in surgically treated intracranial meningioma patients-A retrospective study of 255 meningioma patients.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePersistent peritumoral brain edema (PTBE) following surgery of intracranial meningioma (IM) has recently been proposed to represent, in part, iatrogenic gliosis-like changes (IGCs). We aimed to estimate the frequency of IGCs after gross total resection (GTR) of IM, identify factors associated with IGCs, and assess their effect on surgical outcome.
methodsPatients with IM who underwent surgery between 2000 and 2020, presented with no preoperative PTBE on magnetic resonance imaging, and had at least one year of follow-up were retrospectively identified. Only patients without preoperative PTBE were included to ensure that postoperative hyperintense fluid-attenuated inversion recovery (FLAIR) changes were iatrogenic. Outcomes were evaluated based on postoperative symptoms and changes in Karnofsky Performance Status (KPS).
resultsA total of 255 meningioma patients without preoperative PTBE were identified. Of these, 133 (52.2%) showed postoperative IGCs on FLAIR imaging. IM location (p < .001), volume (p < .001) and World Health Organization grade (p = .003) associated with IGCs in univariate analysis. In multivariate analysis, non-convexity location (OR 2.0-12.2, p = .04 to <.001) and IM volume (OR 1.1, p < .001) remained significant. Patients with IGCs showed a modest KPS improvement from 86.7 to 88.0 (+1.3), while those without IGCs improved more from 90.0 to 92.5 (+2.5, p = .002). IGCs were associated with residual symptoms (OR 2.3, p = .01) and new-onset seizures (OR 6.1, p = .04).
conclusionIGCs are frequent following GTR of IM, and associate with IM location and volume. IGCs likely associate with impaired recovery following surgery and new-onset seizures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.