Evidence map›Paper›PMID 41468441›Full record

ArticlePloS one2025

Integrated transcriptome and metabolome analysis of melanin-related genes and metabolites in Muchuan Black Bones Chickens.

Liu Wei, Jie Hong-Wei, Gao Ming-Chao, Yao Xiu-Mei, Yin Qiong, Xiang Hai, Ma Zheng, Zhang Zheng-Fen, Li Liang, Li Hua and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Liu WeiGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, China.
Jie Hong-WeiGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, China.
Gao Ming-ChaoGuangdong Tinoo's Food Co., Ltd., Qingyuan, China.
Yao Xiu-MeiGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, China.
Yin QiongGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, China.
Xiang HaiGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, China.
Ma ZhengGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, China.
Zhang Zheng-FenGuangdong Tinoo's Food Co., Ltd., Qingyuan, China.
Li LiangAnimal Husbandry and Veterinary Institute of Guizhou Province, Guizhou, China.
Li HuaGuangdong Tinoo's Food Co., Ltd., Qingyuan, China.
Qi HaoGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, China.
Ye FeiGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, China.ORCID https://orcid.org/0000-0003-0059-5377

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Muchuan Black Bones Chickens represent a significant subtype of the Sichuan mountain black bones chickens. In the breeding of black bone chickens, the degree of melanization tends to separate due to hybridization, while molecular-assisted breeding techniques were still limited, and the key genes involved in melanin deposition in the early growth of black bones chickens have yet to be validated. Hypothesize that melanin deposition in Muchuan Black Bones Chickens was governed by specific genetic and metabolic regulators that can be systematically identified. This study aims to identify key genes and metabolites associated with melanin in Muchuan Black Bones Chickens through integrated transcriptomic and metabolomic analyses. CDP-ethanolamine, m-trigallic acid, UDP-4-dehydro-6-deoxy-D-glucose, glucoiberverin, and uridine diphosphate glucuronic acid (UDP glucuronic acid) were identified as significant differential metabolites, which were intimately linked to phenylalanine, tyrosine, and tryptophan biosynthesis associated with melanin accumulation. A total of 73 differentially expressed genes, including cAMP response element-binding protein 5 (CREB5) and GIPC PDZ domain containing family member 2 (GIPC2), were enriched in the neuroactive ligand-receptor interaction pathway, arginine-proline metabolism pathway, histidine metabolism, terpenoid backbone biosynthesis, and glycerophospholipid metabolism. This study identified significant metabolites and regulatory genes associated with melanin synthesis, establishing a theoretical foundation for the breeding and selection of chickens.

Indexed as

ChickensMelaninsMetabolomeTranscriptomeAnimalsGene Expression ProfilingMelanins

Identifiers

PMID41468441
PMCPMC12752978

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.