Evidence map›Paper›PMID 41468219›Full record

ArticleTissue engineering. Part A2026

Dermal Templates Support Epidermal Regeneration and Maturation Regardless of Cell Donor Age.

Autumn C Campbell, Divya Sridharan, Britani N Blackstone, Syed A Ashraf, Dorothy M Supp, Mahmood Khan, Heather M Powell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part A, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Autumn C CampbellDepartment of Materials Science and Engineering, The Ohio State University, Columbus, Ohio, USA.
Divya SridharanDivision of Basic and Translational Sciences, Department of Emergency Medicine, The Ohio State University, Columbus, Ohio, USA.
Britani N BlackstoneDepartment of Materials Science and Engineering, The Ohio State University, Columbus, Ohio, USA.
Syed A AshrafDivision of Basic and Translational Sciences, Department of Emergency Medicine, The Ohio State University, Columbus, Ohio, USA.
Dorothy M SuppShriners Children's Ohio, Dayton, Ohio, USA.
Mahmood KhanDivision of Basic and Translational Sciences, Department of Emergency Medicine, The Ohio State University, Columbus, Ohio, USA.
Heather M PowellDepartment of Materials Science and Engineering, The Ohio State University, Columbus, Ohio, USA.

Funding

Molecular identity of exosomal BK channelsR01HL157453 · NHLBI · OHIO STATE UNIVERSITY · PI Mahmood Khan, HARPREET SINGH · 2022 to 2026
$3.0M
In Situ Skin Regeneration and Angiogenesis for Full-Thickness BurnsR01AR080946 · NIAMS · OHIO STATE UNIVERSITY · PI Mahmood Khan, Heather M Powell · 2023 to 2026
$2.3M
NHLBI NIH HHS R01 HL157453NIAMS NIH HHS R01 AR080946
6 · The paper itself

Abstract

To provide an optimal wound bed for epidermal regeneration, a viable dermis is needed. As the dermis is destroyed in full-thickness burns, dermal templates (DTs) are used to create a healthy dermis for grafting and other procedures. Neonatal foreskin has exclusively been used as the source of dermal fibroblasts in commercial DTs, as the tissue is readily available and because these cells are assumed to be more proliferative and capable of superior wound healing compared with adult fibroblasts. The goal of this study was to assess the function of adult fibroblasts compared with neonatal fibroblasts for DT construction and epidermal regeneration. Primary fibroblasts were isolated from neonatal or adult surgical discard tissue (n = 4 each). Expression of collagen type 1 A1 (

Indexed as

DermisEpidermisFibroblastsRegenerationTissue ScaffoldsAdultCell ProliferationCells, CulturedHumansKeratinocytesMalebasement membranebiological agedermal templatesECM depositionengineered skinfibroblast agere-epithelization

Identifiers

PMID41468219
PMCPMC13255093

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.