Evidence map›Paper›PMID 41468026›Full record

ArticleJournal of Alzheimer's disease : JAD2026

Limited evidence for heart rate variability as a predictor of cognitive and pathophysiological brain markers.

Sofia Marcolini, Jaime D Mondragón, Arie M van Roon, Balewgizie Sileshi Tegegne, Harriëtte Riese, Rozemarijn Vliegenthart, Rudi A J O Dierckx, Ronald H Borra, Peter Paul De Deyn

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Article in Journal of Alzheimer's disease : JAD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sofia MarcoliniDepartment of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-1856-9348
Jaime D MondragónDepartment of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0001-6416-4942
Arie M van RoonDepartment of Vascular Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Balewgizie Sileshi TegegneDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Harriëtte RieseDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Rozemarijn VliegenthartDepartment of Radiology, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0002-7262-3376
Rudi A J O DierckxDepartment of Nuclear Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Ronald H BorraDepartment of Nuclear Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-8072-1243
Peter Paul De DeynDepartment of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundHeart rate variability (HRV) is related to cognitive functioning and may serve as an early Alzheimer's disease biomarker.ObjectiveWe examine whether HRV predicts cognitive and pathophysiological brain markers assessed eight and thirteen years later, independently of coronary calcification.Methods269 cognitively unimpaired adults were selected based on their coronary artery calcification score (absent, score=0; high, score≥300), obtained from cardiac computed tomography scans (T2, 2017-2022). HRV in the time domain (root mean square of successive RR interval differences), measured at T0 (2007-2013), T1 (2014-2017), and the change between T0 and T1, was the predictor. Outcomes included cognitive measures, serum Alzheimer's disease biomarkers, and brain imaging markers obtained at T3 (2022-2023). Linear regression models were run, stratified by coronary calcification groups and adjusted for demographics, lifestyle and cardiometabolic factors.ResultsParticipants with high T2 calcification showed lower HRV at T0 and a positive change compared to those with absent calcification. In participants with high T2 calcification, higher HRV at T0 was associated with lower Aβ

Indexed as

BrainCognitionCognitive DysfunctionHeart RateAgedAlzheimer DiseaseBiomarkersCoronary Artery DiseaseFemaleHumansMaleMiddle AgedNeuropsychological TestsBiomarkersAlzheimer's diseasebiomarkerscognition disordersdementiahealth statusheart rate variability

Identifiers

PMID41468026
PMCPMC13487330

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.