Evidence map›Paper›PMID 41467939›Full record

ArticleJournal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie2025

Role of muscle-related genes in sleep bruxism : Understanding the genetic aspect of this behavior.

Katia Raquel Weber, Joyce Duarte, Helena Polmann, Patrícia Pauletto, Jéssica Conti Réus, Israel Silva Maia, Juliana Feltrin Souza, Marcia Regina Pincerati, Erika Calvano, Graziela De Luca Canto and 1 more

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Article in Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Katia Raquel WeberPositivo University, Curitiba, Brazil.
Joyce DuarteUnicuritiba University Center, Curitiba, Brazil.
Helena PolmannUniversidade Federal de Santa Catarina, Florianópolis, Brazil.
Patrícia PaulettoUniversidad de Las Américas, Quito, Ecuador.
Jéssica Conti RéusUniversidade Federal de Santa Catarina, Florianópolis, Brazil.
Israel Silva MaiaBaía Sul Research Institute, Florianópolis, Brazil.
Juliana Feltrin SouzaFederal University of Paraná, Curitiba, Brazil.
Marcia Regina PinceratiPositivo University, Curitiba, Brazil.
Erika CalvanoDepartment of Orthodontics, University Hospital Bonn, Medical Faculty, Bonn, Germany.
Graziela De Luca CantoUniversidade Federal de Santa Catarina, Florianópolis, Brazil.
João Armando BrancherPositivo University, Curitiba, Brazil. brancher.a@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo test the hypothesis that single nucleotide polymorphisms (SNPs) in the muscle-related genes actinin alpha 3 (ACTN3), creatine kinase muscle (CKM), and angiotensin I converting enzyme (ACE) are associated with sleep bruxism (SB).

methodsThis study involved 45 individuals diagnosed with SB through self-report questionnaires, clinical examination, and polysomnography. Deoxyribonucleic acid samples were collected, and three SNPs, rs1815739 in ACTN3, rs8111989 in CKM, and rs4341 in ACE, were selected for genotyping via real-time PCR. The associations between SB and SNPs were investigated with genotypic, allelic, recessive, and dominant models via the χ

resultsSixteen individuals, 11 males (68.7%) and 5 females (31.3%), were diagnosed with SB. Another 29 individuals (16 males and 15 females) without bruxism were included in the control group. For rs1815739, the CC genotype was associated with a high prevalence of SB (p = 0.032). In the recessive model, homozygous CC individuals presented 392% greater odds for SB than individuals with CT/TT (OR 4.92; 95%CI 1.29-18.73). No differences were observed for rs8111989 and rs4341 in the tested models (p > 0.05).

conclusionPolymorphism rs1815739 in ACTN3 was associated with SB.

Indexed as

ACTN3 geneGenetic polymorphismsMasticatory muscle activityPolysomnographySingle nucleotide polymorphisms

Identifiers

PMID41467939

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