Evidence map›Paper›PMID 41467851›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2026

Acute arrhythmias in a long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency mouse model.

Gabriela Elizondo, Arianna Scalco, Ayah Asal, Hak Chung, Garen Gaston, Beth A Habecker, Melanie B Gillingham

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Gabriela ElizondoDepartment of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0002-1009-0068
Arianna ScalcoDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, United States.
Ayah AsalDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0009-0002-3597-1643
Hak ChungDepartment of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0002-4315-3897
Garen GastonDepartment of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, United States.
Beth A HabeckerDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0002-4658-8730
Melanie B GillinghamDepartment of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0003-0897-8268

Funding

Neurotrophins and post-infarct plasticity in cardiac sympathetic neuronsR01HL093056 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BETH A HABECKER · 2009 to 2026
$7.9M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) NIH R01 HL093056NHLBI NIH HHS R01 HL093056Patterson Foundation (The Patterson Foundation)Portland State University (PSU) URISE Program
6 · The paper itself

Abstract

Patients with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD), a mitochondrial fatty acid oxidation (FAO) disorder, frequently present with cardiomyopathy and can suffer from life-threatening arrhythmias and heart failure. Although these remain the leading causes of death, the pathophysiology remains unknown. We used an LCHADD mouse model to examine the mechanisms of impaired cardiac function. We previously determined that LCHADD mice (

Indexed as

3-Hydroxyacyl CoA DehydrogenasesArrhythmias, CardiacCardiomyopathiesHeart RateLipid Metabolism, Inborn ErrorsAnimalsDisease Models, AnimalLong-Chain-3-Hydroxyacyl-CoA DehydrogenaseMaleMiceMice, Inbred C57BLMyocytes, CardiacOxidative StressPhenotype3-Hydroxyacyl CoA DehydrogenasesLong-Chain-3-Hydroxyacyl-CoA Dehydrogenasearrhythmiafatty acid oxidationhypertrophic cardiomyopathylipotoxicitylong-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD)

Identifiers

PMID41467851
PMCPMC12897990

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.