Evidence map›Paper›PMID 41467843›Full record

ArticleInfection and immunity2026

Intralysosomal pathogens differentially influence the proteolytic potential of their niche.

Lauren E Bird, Bangyan Xu, David R Thomas, Erin N S McGowan, Patrice Newton, Nichollas E Scott, Malcolm J McConville, Laura E Edgington-Mitchell, Hayley J Newton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lauren E BirdDepartment of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0001-7082-3115
Bangyan XuDepartment of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-2156-9074
David R ThomasDepartment of Microbiology, Infection Program, Monash Biomedicine Discovery Institute, Melbourne, Victoria, Australia.
Erin N S McGowanDepartment of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.
Patrice NewtonDepartment of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0001-9004-6501
Nichollas E ScottDepartment of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0003-2556-8316
Malcolm J McConvilleDepartment of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-7107-7887
Laura E Edgington-MitchellDepartment of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-6810-6149
Hayley J NewtonDepartment of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-9240-2001

Funding

National Health and Medical Research Council 2010841National Health and Medical Research Council 2011119
6 · The paper itself

Abstract

Avoiding lysosomal degradation is vital to the success of intracellular pathogens. The Gram-negative bacterium

Indexed as

Coxiella burnetiiLeishmania mexicanaLysosomesPhagosomesCathepsin BHost-Pathogen InteractionsHumansMacrophagesProteolysisTHP-1 CellsCathepsin Bcathepsin Bcathepsin Dco-infectionCoxiella burnetiiLeishmania mexicana

Identifiers

PMID41467843
PMCPMC12890031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.