Evidence map›Paper›PMID 41467787›Full record

ArticlemBio2026

Acute malaria dysregulates specialized lymph node macrophages to suppress vaccine-elicited protection against the Ebola virus.

Jonah Elliff, Lindsey Grady, Kyle L O'Donnell, Caitlin Messingham, Kai J Rogers, Jobaida Akther, Andrew Thurman, Rahul Vijay, Alejandro Pezzulo, Troy Randall and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jonah ElliffInterdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0001-8129-2997
Lindsey GradyDepartment of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
Kyle L O'DonnellLaboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Caitlin MessinghamDepartment of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
Kai J RogersDepartment of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
Jobaida AktherDepartment of Medicine, Divisions of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Heersink School of Medicine, Birmingham, Alabama, USA.
Andrew ThurmanDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Rahul VijayRosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.
Alejandro PezzuloDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Troy RandallDepartment of Medicine, Divisions of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Heersink School of Medicine, Birmingham, Alabama, USA.
Andrea MarziLaboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.ORCID 0000-0003-0186-9587
Noah S ButlerInterdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0002-1429-0796
Wendy MauryInterdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0002-9892-4484

Funding

Molecular Analysis and Lineage Tracing of Influenza-Specific, Lung-Resident Memory B CellsR01AI152476 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RANDALL, TROY D · 2020 to 2025
$5.5M
PREDOCTORAL TRAINING PROGRAM IN IMMUNOLOGYT32AI007485 · NIAID · UNIVERSITY OF IOWA · PI Kevin L Legge · 1995 to 2026
$5.4M
Regulation of Plasmodium-specific CD4+ T CellsR01AI127481 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Noah Sullivan Butler · 2016 to 2026
$3.8M
Development and function of CD4+ memory T cells during malariaR01AI125446 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Noah Sullivan Butler · 2016 to 2026
$3.7M
Protective functions of influenza-specific lung-resident memory B cellsR01AI153413 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RANDALL, TROY D · 2020 to 2025
$3.5M
Mechanisms and consequences of extrafollicular B cell activation during malariaR01AI167058 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN · 2021 to 2025
$3.2M
Mechanisms and consequences of Plasmodium/Ebola virus co-infectionsR21AI139902 · NIAID · UNIVERSITY OF IOWA · PI MAURY, WENDY JEAN · 2018 to 2019
$453k
Defining the effect of Plasmodium infection on Ebola virus vaccine efficacyUH2AI174415 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, MAURY, WENDY JEAN · 2023 to 2024
$428k
Evaluating the impact of malaria on immunogenicity of the Ebola virus vaccineF30AI181340 · NIAID · UNIVERSITY OF IOWA · PI Jonah Elliff · 2024 to 2026
$127k
NIAID NIH HHS F30 AI181340NIAID NIH HHS R01 AI125446NIAID NIH HHS R01 AI127481NIAID NIH HHS R01 AI152476NIAID NIH HHS R01 AI153413NIAID NIH HHS R01 AI167058NIAID NIH HHS R21 AI139902NIAID NIH HHS T32 AI007485NIAID NIH HHS UH2 AI174415
6 · The paper itself

Abstract

The filovirus, Ebola virus (EBOV), causes outbreaks of EBOV disease (EVD) throughout equatorial Africa. ERVEBO is a replication-competent recombinant vesicular stomatitis virus-vectored vaccine encoding the EBOV glycoprotein (recombinant vesicular stomatitis virus [rVSV]/EBOV), which is licensed to control EVD outbreaks. EVD outbreaks occur in regions endemic for IMPORTANCE: We show that a blood-stage murine

Indexed as

Ebola VaccinesEbolavirusHemorrhagic Fever, EbolaLymph NodesMacrophagesMalariaAnimalsAntibodies, ViralFemaleInterferon-gammaMiceVaccines, SyntheticVesiculovirusAntibodies, ViralEbola VaccinesInterferon-gammaVaccines, SyntheticCD169 macrophagesEbola virusfilovirusinterferon gammalymph nodePlasmodiumvaccine

Identifiers

PMID41467787
PMCPMC12892958

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.