Evidence map›Paper›PMID 41467764›Full record

ArticleAmerican journal of physiology. Cell physiology2026

Plasma extracellular vesicle signatures of metabolic health and exercise response in a pilot study of older adults.

Xin Zhang, William E Kraus, Joseph A Houmard, Johanna L Johnson, Virginia Byers Kraus

Abstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. RYR1Journal of translational medicine · 2026
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xin ZhangDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, United States.ORCID 0000-0001-7390-4439
William E KrausDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, United States.ORCID 0000-0003-1930-9684
Joseph A HoumardDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, United States.ORCID 0000-0003-3682-5410
Johanna L JohnsonDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, United States.ORCID 0000-0001-9766-1814
Virginia Byers KrausDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, United States.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Extracellular Vesicle Analyses to Develop Aging and Resilience BiomarkersR01AG070146 · NIA · DUKE UNIVERSITY · PI KRAUS, VIRGINIA B · 2021 to 2025
$3.1M
Skeletal Muscle Molecular Drug Targets for Exercise-induced Cardiometabolic HealthR01HL153497 · NHLBI · DUKE UNIVERSITY · PI KRAUS, WILLIAM E · 2021 to 2024
$2.8M
NCI NIH HHS P30 CA016086NHLBI NIH HHS R01 HL153497NIA NIH HHS R01 AG070146
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are key mediators of intercellular communication and regulators of cellular function, yet their roles in metabolic health and exercise response are poorly understood. This pilot study analyzed plasma from older adults (

Indexed as

ExerciseExtracellular VesiclesAgedBiomarkersFemaleHumansInsulinInsulin ResistanceMaleMiddle AgedMuscle, SkeletalPilot ProjectsBiomarkersInsulinexerciseextracellular vesicleimmune cellsmetabolic healthmuscle

Identifiers

PMID41467764
PMCPMC12866931

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.