ArticleAIDS (London, England)2026
Tolerability of lopinavir versus dolutegravir in children and adolescents with HIV.
Article in AIDS (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- HIV drug resistance amongst children and adolescents with viraemia in Lesotho and Tanzania: a nested analysis in the GIVE MOVE trial.The Journal of antimicrobial chemotherapy · 2026Trial
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Authors and funding
16 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren and adolescents with HIV previously taking ritonavir-boosted lopinavir (LPV/r)-based antiretroviral therapy (ART) were recently programmatically transitioned to dolutegravir (DTG)-based ART in Lesotho, southern Africa. We investigated associated changes in treatment satisfaction and potential side effects.
methodsThis single-center prospective cohort study enrolled participants younger than 18 years transitioned from LPV/r-based to DTG-based ART during the national programmatic DTG rollout in 2022-2023. Virally suppressed participants who were at least 6 years old and able to handle a sleep diary and actigraphy were eligible for additional sleep monitoring. Enrollment occurred 2 weeks before (with actigraphy) or at (without actigraphy) transition with follow-up until 4 weeks posttransition. Co-primary endpoints were change in treatment satisfaction assessed with the HIV Treatment Satisfaction Questionnaire change version (HIVTSQc; Teen and Parent versions) at 4 weeks, and difference in mean sleep period length over a 2-week period before and after transition (only actigraphy participants). Secondary endpoints assessed treatment satisfaction status, gastrointestinal symptoms, depressive symptoms, and additional sleep measures.
resultsAmong 245 participants with transition and 4-week data, 115 (47%) were girls and median age was 11.1 (interquartile range 8.9-13.6) years. HIVTSQc outcomes favored DTG, with 88/92 (96%) HIVTSQc-Teen and 149/151 (99%) HIVTSQc-Parent responses indicating being 'much more satisfied now' posttransition. Among 69 (28%) actigraphy participants, mean sleep period length was 9.0 h [standard deviation (SD) 1.0] before and 9.2 h (SD 1.0) 2-4 weeks posttransition [mean difference 0.2, 95% confidence interval (CI) 0.0-0.4]. Secondary outcomes did not change meaningfully.
conclusionObserved treatment satisfaction and tolerability support the rollout of DTG in pediatric HIV care.
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