SynthesisJournal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology2026
Clinicopathological Analysis and Survival Outcomes of Radiation-Induced Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.
Synthesis in Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Clinicopathological Analysis and Survival Outcomes of Radiation-Induced Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026Pooled it
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRadiotherapy-induced malignancies are well-documented, but the clinicopathological profile and prognostic factors of radiation-induced oral squamous cell carcinoma (R-OSCC) remain unclear.
methodsThe present review was conducted in accordance with the PRISMA guidelines and has been registered in the PROSPERO (registration number CRD42024560015). A comprehensive search was performed across electronic databases and gray literature sources. The risk of bias was assessed using the JBI tool. Meta-analysis was performed with Review Manager 5.4.
resultsFive cohort studies were included (n = 310), with four pooled in a meta-analysis. R-OSCC was significantly associated with tongue tumors (p = 0.007) and early clinical stages (p < 0.0001). Negative perineural invasion was linked to sporadic OSCC (p = 0.0008). Smoking (p = 0.0008) and radiotherapy (RT) history (p < 0.00001) were associated with decreased overall survival (OS), while RT history also reduced disease-specific survival (DSS) in R-OSCC patients (p = 0.006).
conclusionsR-OSCC predominantly affects the tongue, is diagnosed in early stages, and the history of RT is associated with reduced OS and DSS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.